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This study aims to conduct a comprehensive analysis by integrating clinical factors, aneurysm morphological characteristics, and factors reflecting pathophysiological processes (such as hemodynamic and radiomics features), in order to explore the hemodynamic mechanisms associated with the progression of intracranial dissecting aneurysms. Furthermore, artificial intelligence algorithms will be employed to develop and validate an intelligent risk prediction model for the progression and outcomes of intracranial dissecting aneurysms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group (Non-progression Group) | Imaging progression of intracranial dissecting aneurysms during follow-up | ||
| Experimental Group (Progression Group) | Imaging progression of intracranial dissecting aneurysms during follow-up |
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| Measure | Description | Time Frame |
|---|---|---|
| Progression of intracranial dissecting aneurysms | From enrollment to 12 months of follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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The target population consists of patients with intracranial artery dissection (IAD) who received care at the study institution between 2015 and 2025. Eligible participants are adults aged 18-80 years with IAD confirmed by both digital subtraction angiography (DSA) and high-resolution MRI (HR-MRI) according to the imaging diagnostic criteria proposed in the Chinese expert consensus on intracranial artery dissection. Participants are managed with conservative treatment and undergo follow-up, and they provide written informed consent. Key exclusions include arteritis, fibromuscular dysplasia, iatrogenic or traumatic pseudoaneurysm; contraindications to MRI or cerebral angiography (e.g., implanted metallic foreign bodies, claustrophobia, or iodinated contrast allergy); extracranial dissection extending intracranially or concomitant intracranial atherosclerotic plaque in the affected vessel; refusal of MRI; severe comorbidities with an expected survival of less than 2 years; or absence of
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Tiantan Hospital, Capital Medical University | Beijing | Beijing Municipality | 107000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28826706 | Result | Li W, Liu J, Zhang Y, Wang K, Tian Z, Zhang Q, Jiang C, Yang X, Wang Y. Flow Diversion and Outcomes of Vertebral Fusiform Aneurysms After Stent-Only Treatment: A Hemodynamic Study. World Neurosurg. 2017 Nov;107:202-210. doi: 10.1016/j.wneu.2017.07.157. Epub 2017 Aug 4. | |
| 32792460 | Result | Zhang Y, Tian Z, Zhu W, Liu J, Wang Y, Wang K, Zhang Y, Yang X, Li W. Endovascular treatment of bilateral intracranial vertebral artery aneurysms: an algorithm based on a 10-year neurointerventional experience. Stroke Vasc Neurol. 2020 Sep;5(3):291-301. doi: 10.1136/svn-2020-000376. Epub 2020 Aug 13. |
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To protect patient privacy, the decision was made not to share the data.
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| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D002532 | Intracranial Aneurysm |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D020765 | Intracranial Arterial Diseases |
| D000783 | Aneurysm |
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