Extracorporeal Blood Purification Using Oxiris for Septic Shock (EXPLORE Study)

Efficacy of eXtracorPoreal bLOod puRification Using oXiris in Patients With SEptic Shock: A Multicenter Propensity-matched Cohort Study (EXPOLRE Study)

The goal of this clinical trial is to evaluate if a blood purification treatment called "Oxiris" works to help adults with septic shock. The main questions it aims to answer are: (1) Does Oxiris treatment lower the risk of death or organ failure within the first 7 days? (2) Does Oxiris treatment lower the level of inflammation in the body? Researchers will compare participants who receive Oxiris treatment to a group of participants who receive standard medical care to see if Oxiris helps them recover better.

Participants will:

1. Receive blood purification therapy using the Oxiris filter for up to 3 days while in the intensive care unit (ICU).
2. Have their blood tested at the start of the study and 3 days later to check for inflammation and organ function.
3. Be followed by the research team for about 30 days to check on their health and recovery.

Inclusion Criteria:

• Participants must be 19 years of age or older.
• Participants must be diagnosed with septic shock (a severe body-wide response to infection that leads to dangerously low blood pressure).
• Participants must be in a condition where the medical team has decided that blood purification therapy (like CRRT) is necessary.

Exclusion Criteria:

• People who have a "Do Not Resuscitate" (DNR) order or are not expected to survive more than 24 hours.
• People who are pregnant or breastfeeding.
• People who are known to be allergic to the materials used in the Oxiris filter (such as heparin or specific plastics).
• People who are already participating in another clinical trial that might affect the results of this study.
• People whom the doctor decides are not suitable for the study for other medical safety reasons.