Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Pneumonia is a major threat to the health of children. Mycoplasma pneumoniae infection is a core cause of pediatric pneumonia, and the incidence of severe mycoplasma pneumoniae pneumonia (SMPP) has increased in recent years. SMPP leads to a range of extrapulmonary symptoms, including myocardial and liver injury, which may be life-threatening. Therefore, there is an urgent need to establish an early warning model for SMPP to improve the prognosis of pediatric pneumonia. This observational study aims to establish a early prediction model of SMPP. Development cohorts are enrolled from Beijing Friendship Hospital between 2018-1-1 to 2024-5-31, and validation cohorts are enrolled between 2024-6-1 to 2025-6-30.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Development | A primary cohort of eligible patients from the Beijing Friendship Hospital between 2018-1-1 and 2024-5-31 is used for model derivation. |
| |
| Internal cross-validation | A cohort of consecutive patients from the Beijing Friendship Hospital between 2018-1-1 and 2024-5-31 is used for internal cross-validation. |
| |
| External validation | A cohort of patients from the Beijing Friendship Hospital between 2024-6-1 and 2025-6-30 is used for internal cross-validation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| medical history taking, blood test, pulmonary ultrasound | Other | medical history taking, blood test, pulmonary ultrasound are used for MPP and SMPP diagnosis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Area under the curve (AUC) | The AUC of prediction model for SMPP | through the hospitalization, an average of 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity | The sensitivity of prediction model for SMPP | through the hospitalization, an average of 7 days |
| Specificity | Specificity of prediction model for SMPP |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Children hospitalized at Beijing Friendship Hospital between 2018-01-01 and 2024-06-01, diagnosed with MPP, and with a hospital stay > 3 days (aged 1 month to 14 years) were enrolled. According to disease severity, they were divided into the mild MPP (MPP group) and severe MPP (SMPP group).
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Friendship Hospital | Beijing | Beijing Municipality | 100050 | China |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D011019 | Pneumonia, Mycoplasma |
| ID | Term |
|---|---|
| D009175 | Mycoplasma Infections |
| D009180 | Mycoplasmatales Infections |
| D016905 | Gram-Negative Bacterial Infections |
| D001424 | Bacterial Infections |
Not provided
Not provided
| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
Not provided
Not provided
Not provided
Not provided
Not provided
| through the hospitalization, an average of 7 days |
| Positive prediction value (PPV) | Positive prediction value (PPV) of prediction model for SMPP | through the hospitalization, an average of 7 days |
| Negative prediction value (NPV) | Negative prediction value (NPV) of prediction model for SMPP | through the hospitalization, an average of 7 days |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D018410 | Pneumonia, Bacterial |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |