The goal of this observational study is to 1) better understand and predict biological processes before disease begins or is identified, 2) study genomic and environmental contributors to disease, 3) identify ways to stop disease advancement before it becomes serious or complex, and 4) identify potential targets for disease therapy.

Participants will be asked to:

• collect biological samples,
• download a mobile app,
• collect speech (voice) recordings, and
• complete surveys

Inclusion Criteria:

• Age ≥ 18 years
• Registered Mayo Clinic patient
• Able to provide informed written consent
• Able to receive mail and packages within a United States (US) state
• Able to collect and ship samples within a US state via FedEx for overnight delivery

Exclusion Criteria:

• Active hematological cancer or history of a hematological cancer
• Allogeneic Bone Marrow Transplant (autologous bone marrow transplant recipients are acceptable if collected at least one month after transplant)
• Other co-morbidity that, in physician's opinion, would interfere with patient's ability to participate in the study (e.g., reduced ability to comprehend, i.e., dementia, intellectual disability, etc.)

Mayo Clinic patients