Oral leukoplakia (OL) is recognized as the most common potentially malignant disorder of the oral mucosa. The pathogenesis of OL is complex and multifactorial, with oxidative stress playing a central role. Topical antioxidants have gained attention as therapeutic options to help stabilize lesions and potentially prevent malignant transformation. Both CoQ10 and curcumin have demonstrated a clinical success as strong antioxidants showing their capacity to reduce the lesion size and to stabilize the disease, ultimately preventing progression into oral malignancy. Aim: This study aims to clinically and biochemically assess the effectiveness of topical Coenzyme Q10 and Curcumin in the management of homogeneous oral leukoplakia.

Inclusion Criteria:

• Clinically and histologically diagnosed with homogeneous oral leukoplakia not indicated for surgical excision .
• Lesions accessible for topical application.
• Willing to sign informed consent and comply with study instructions and return to follow up

Exclusion Criteria:

• Moderate-to-severe dysplasia, carcinoma in situ, or invasive oral cancer.
• Presence of any visible oral lesions except for oral leukoplakia.
• Active periodontal diseases as this can confound salivary biomarkers.
• Significant systemic illness or immunosuppression.
• Patients who have taken systemic or topical antioxidant supplements within the last four weeks will be excluded to avoid confounding effects on salivary biomarkers.
• Pregnant and lactating women will be excluded due to hormonal changes that may alter oxidative stress and ethical considerations.
• Patients unwilling or unable to comply with study requirements.