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This study uses number and size of ovarian follicles on the day of ovulation trigger as key determinants for oocytes yield to optimize outcomes in IVF and ICSI Protocols
Accurate prediction of oocyte yield is a key factor in optimizing outcomes of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles. Follicle number and follicle diameter measured on the day of ovulation trigger are known to be strongly associated with oocyte retrieval and oocyte maturity. Larger follicles are more likely to yield mature (metaphase-II) oocytes, while smaller follicles contribute less consistently to oocyte yield.
Despite the established association between follicular size and oocyte maturity, there is currently no standardized clinical model that estimates the minimum expected number of retrieved oocytes based on the distribution of follicle diameters on the trigger day. Most existing studies focus on average outcomes rather than providing a practical tool to estimate the lowest anticipated oocyte yield for individual patients.
This study aims to estimate the minimum number of oocytes retrieved based on the number and diameter of ovarian follicles measured on the day of ovulation trigger. By developing a predictive approach based on follicular size distribution, this study seeks to support clinical decision-making, optimize trigger timing, and improve patient counseling regarding realistic expectations of oocyte yield.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ICSI observational Cohort | Participants will undergo standard ICSI procedures. Follicle size and number will be measured during ovarian stimulation; and oocyte yield will be see corded at retrieval. No additional interventions will be performed. The study aims to evaluate the predictive relationship between follicle characteristics and Oocyte yield |
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| Measure | Description | Time Frame |
|---|---|---|
| Total number of oocytes retrieved per participant during an ICSI cycle | The total number of oocytes retrieved will be recorded for each participant. Follicular number and mean follicular diameter will be measured by transvaginal ultrasound during ovarian stimulation, and their association with oocyte yield will be analyzed to determine minimum predictive thresholds for successful oocyte retrieval. | From the start of controlled ovarian stimulation until the day of oocyte retrieval, assessed at oocyte retrieval (approximately 10-14 days after stimulation initiation and 34-36 hours after ovulation trigger). |
| Measure | Description | Time Frame |
|---|---|---|
| Oocyte yield stratified by follicle size category and age group | The total number of oocytes retrieved per participant will be recorded and analyzed according to follicle size categories on the day of ovulation trigger. Participants will be stratified into predefined age groups (18-29 years and 30-35 years), and oocyte yield per follicle size category will be compared between age groups. | From the start of controlled ovarian stimulation until the day of oocyte retrieval, assessed at oocyte retrieval (approximately 10-14 days after stimulation initiation and 34-36 hours after ovulation trigger). |
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Inclusion Criteria:
Exclusion Criteria:
Only female participants are eligible because the study focuses on Oocyte retrieval during ICSI, which is a procedure performed in women
Female participants aged 18 to 35 years undergoing ICSI
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmad Rashad Mahmoud Mostafa, MBBCh | Contact | +201015655880 | dr.arm99256@outlook.com | |
| Karima Sobhy M.Kholeif, Ph.D. | Contact | +01092698985 | Karema55@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Alaa Ahmed Makhlouf, MD | Assiut University | Study Chair |
| Ahmed Abo-Elfadle, MD | Assiut University | Study Chair |
| Ahmed Mohamed Abo Elhasan Morsy, MD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assiut University | Asyut | Asyut Governorate | 71511 | Egypt |
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| Label | URL |
|---|---|
| This website provides the official ESHRE guidelines on a Varian stimulation, follicle monitoring and IVF and ICSI protocols, including definitions of poor ovarian response, which informed the design of this study | View source |
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No plan to share individual participant data is currently in place for this study
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| ID | Term |
|---|---|
| D007247 | Infertility, Female |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| Assiut University |
| Study Chair |
| D000091662 | Genital Diseases |
| D007246 | Infertility |