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The pathophysiology of adolescent idiopathic scoliosis is unknown. This pathology develops from 10-11 years of age and progresses until skeletal maturity, or even adulthood for the most severe forms.
Current knowledge is limited as to its origin on the one hand and the evolutionary nature of scoliosis on the other.
The mechanical parameters of the intervertebral disc are incompletely known from the deep location of this organ, its fragile nature in vivo and its susceptibility to desiccation during ex-vivo analysis.
To complete our knowledge of the mechanical parameters of the intervertebral disc of scoliotic and non-scoliotic children, we are proposing an in vivo, non-invasive and non-irradiating study carried out in children who are the main target of this pathology.
The objective of this work is to characterize the diffusion parameters (apparent diffusion coefficient ADC) of the intervertebral disc in vivo, in a non-invasive and non-irradiating manner by magnetic resonance imaging in children and adolescents. As this measurement has not been carried out in children and adolescents, we want to perform these MRI scans in children free from scoliosis and carriers of scoliosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Scoliotic patients | children with spinal deformity characterized by a hump on clinical examination and a radiological deformation in the coronal plane greater than 10 ° . |
| |
| Non scoliotic patients | Childrne with no hump on clinical examination, able to walk. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| magnetic resonance imaging of the lumbar or spinal region | Other | The duration of the acquisition sequence between 2 and 10 minutes additional compared to a conventional magnetic resonance imaging examination. |
| Measure | Description | Time Frame |
|---|---|---|
| measurement of the value of Apparent Diffusion Coefficient (ADC) in magnetic resonance imaging. | between Day 15 and Day 90 |
| Measure | Description | Time Frame |
|---|---|---|
| Apparent Diffusion Coefficient difference for scoliosis and non-scoliosis patients for one level | between Day 15 and Day 90 | |
| Correlation between right and left Apparent Diffusion Coefficient and inclination of two vertebra for scoliosis patients | between Day 15 and Day 90 |
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Inclusion Criteria:
Exclusion Criteria:
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children and adolescents with and without scoliosis seen in consultation and requiring magnetic resonance imaging of the lumbar region
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Quentin BALLOUHEY, MD | Contact | +33555052410 | quentin.ballouhey@chu-limoges.fr | |
| Edouard LOEVENBRUCK | Contact | Edouard.LOEVENBRUCK@chu-limoges.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Limoges University Hospital | Recruiting | Limoges | 87042 | France |
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| ID | Term |
|---|---|
| D012600 | Scoliosis |
| ID | Term |
|---|---|
| D013121 | Spinal Curvatures |
| D013122 | Spinal Diseases |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
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| gagCEST(Chemical Exchange Saturation Transfer) measurement in magnetic resonance imaging of the discs | between Day 15 and Day 90 |
| Toulouse University Hospital | Not yet recruiting | Toulouse | 31059 | France |
|