This is a Phase 1 study to evaluate the safety, tolerability, PK, and PD of ABF-101 in healthy participants and participants with age-related macular degeneration (AMD).

Part A will be a randomized, double-blind, placebo-controlled, single ascending dose (SAD) study in healthy participants.

Part B will be a randomized, double-blind, placebo-controlled, multiple ascending doses (MAD) study in healthy participants.

Part C will be an open-label study in participants with AMD. For Part A and B, serial blood samples will be collected to assess the PK of ABF-101. Ocular examinations will be conducted to evaluate changes in ocular characteristics and function.

Inclusion Criteria:

• Part A and B

  1. Healthy participants, aged between 18 and 50 years
  2. Provides written, signed, informed consent prior to selection
  3. BMI of ≥ 18.0 and < 32.0 kg/m2, and body weight between 50 kg and 115 kg, inclusive.
  4. Vital signs: normal pulse rate and blood pressure.
  5. Nonsmoker
  6. Must be willing to abstain from caffeine and alcohol
  7. Must be willing to avoid strenuous activity

• Part C

  1. Confirmed diagnosis of AMD
  2. Male or female ≥50 years of age
  3. Adequate visual acuity in the non-study eye

Exclusion Criteria:

• Part A and B

  1. Any history or presence of cardiovascular, pulmonary, gastrointestinal, hepatic, renal, metabolic, hematological, neurologic, psychiatric, systemic, or infectious disease
  2. Any significant abnormalities detected during ocular examination,
  3. Presence or history of drug hypersensitivity, or allergic disease diagnosed and treated by a physician
  4. Any drug intake (except paracetamol or contraceptives)
  5. History or presence alcohol abuse
  6. History or presence of drug abuse
  7. Positive HBsAg or anti-HCV antibody, or positive results for HIV
  8. Blood donation, significant blood loss, or has received a transfusion of any blood or blood products
  9. Female participants who are breastfeeding.
  10. Female participants must not be pregnant or at risk to become pregnant during the study. Male and female participants must agree to use highly effective contraception
  11. Participant who, in the judgment of the Investigator, is likely to be non-compliant or uncooperative during the study, or unable to cooperate because of a language barrier or poor mental development

Part C

1. Evidence of CNV due to any cause other than AMD
2. History of vitreoretinal surgery
3. Significant ocular diseases that may interfere with the study
4. Significantly impaired renal or hepatic function
5. Use of immunosuppressive drugs
6. Use of any investigational agent or participation in any other clinical trial of an investigational agent or investigational therapy
7. History of severe drug allergies or drug hypersensitivity syndrome
8. Undiagnosed acute illness first observed during screening or between screening and baseline, or severe concurrent medical conditions that, in the investigator's judgment, represent a safety concern.
9. Severe cardiac disease.
10. QTc ≥450 msec or participants with a history of risk factors or other clinically significant ECG abnormalities
11. Stroke or transient ischemic attack
12. Any major surgical procedure w
13. Serious active infection, other serious medical condition or any other condition that would impair the ability of the participant to administer the investigational drug or to adhere to the study protocol requirements
14. Presence of any condition which, in the judgment of the investigator, would prevent the participant from completing the study