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The goal of this clinical trial is to see if a nurse-led program (early movement, leg-sleeve squeezes, and blood tests) can prevent dangerous leg blood clots in adults who have just had brain or spine surgery.
Main questions it aims to answer:
Researchers will compare patients who receive the nurse-led program with patients who receive standard hospital care.
Participants will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nurse-led prevention group | Experimental | In addition to routine post-operative care, participants assigned to the nurse-led prevention arm receive:
All steps are recorded in the electronic nursing chart and coordinated by a neurosurgery-rehabilitation-data |
|
| Standard post-neurosurgical care group | No Intervention | Participants in the control arm receive the hospital's standard post-neurosurgical care, which follows current Chinese and U.S. VTE-guidelines and includes:
No systematic Caprini re-assessments, no scheduled early-mobilization protocol, no IPC machines, no D-dimer surveillance, and no activity trackers are used. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| nurse-led program (early movement, leg-sleeve squeezes, and blood tests) | Behavioral | Graded early-movement plan starting within 24 h of surgery
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of objectively confirmed lower-extremity deep-vein thrombosis (DVT) | diagnosed by blinded duplex ultrasound using standard non-compressibility or intraluminal thrombus criteria. | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Time from surgery to first objectively confirmed DVT (days) | Time from surgery to first objectively confirmed DVT (days) | 30 days |
| All-cause mortality within 30 days | All-cause mortality within 30 days |
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Inclusion Criteria
Exclusion Criteria
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| West China Hospital of Sichuan University | Chengdu | Sichuan | China |
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| ID | Term |
|---|---|
| D020246 | Venous Thrombosis |
| ID | Term |
|---|---|
| D013927 | Thrombosis |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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| 30 days |