Chronic kidney disease (CKD) is often associated with multiorgan complications, including thyroid hormone dysfunction. Interleukin-6 (IL-6), a pro-inflammatory cytokine, has been proposed as a marker of inflammation that may contribute to these alterations. The main question it aims to answer is:

Is there an association between interleukin-6 and thyroid hormone dysfunction in patients with chronic kidney disease (CKD) Blood samples will be collected and analyzed from 65 patients who have undergone hemodialysis for at least 3 months.

This cross-sectional observational study involves patients with CKD undergoing hemodialysis at Airlangga University Hospital. Data were collected based on their medical record and Blood test for IL-6. Linear regression analysis assessed the relationship between IL-6 levels and thyroid function parameters.

Inclusion Criteria:

• Age 21 Years Old and above
• Patients with ESRD who have undergone hemodialysis for ≥ 3 months and are in stable condition.
• Patients are able to communicate and respond to questions appropriately
• Patients are willing to participate in the study.

Exclusion Criteria:

• ESRD patients undergoing hemodialysis who have been diagnosed with underlying thyroid disorders or thyroid malignancy.
• Patients with a history of thyroid surgery or any intervention involving the thyroid gland.
• Patients with a family history of thyroid disorders.
• Patients taking medications that affect thyroid function or using antioxidant drugs.
• Patients with infection or sepsis.

The target population consists of all ESRD patients aged ≥ 21 years who undergo examinations at the Dialysis Unit of Universitas Airlangga Hospital, Surabaya. The accessible population includes all ESRD patients aged ≥ 21 years who undergo examinations at the Dialysis Unit of Universitas Airlangga Hospital, Surabaya, during the study period.