Prevalence of Cerebral Large Vessel Occlusion Among Acute... | NCT07326410

Studies
Prevalence of Cerebral Large Vessel Occlusion Among Acute Ischemic Stroke Patients in Assiut University Hospitals

NCT07326410

Sponsor

Assiut University

Status

Not yet recruiting

Last Update Posted

Jan 8, 2026Actual

Enrollment

300Estimated

Phase

Not provided

Conditions

Ischemic Stroke

Interventions

Not provided

Countries

Not provided

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Sep 2025

Overall Recruitment Status or Expanded Access Status

Not yet recruiting

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Feb 1, 2026Estimated

Primary Completion Date

Feb 1, 2027Estimated

Completion Date

Mar 1, 2027Estimated

First Submitted Date

Dec 8, 2025

First Submission Date that Met QC Criteria

Dec 24, 2025

First Posted Date

Jan 8, 2026Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Dec 24, 2025

Last Update Posted Date

Jan 8, 2026Actual

Oversight Module

Has Data Monitoring Committee (DMC)

Yes

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

Prevalence of Large Vessel Occlusion among acute ischemic stroke patients in Assiut University hospitals

Study Objectives

Primary Objective:

- To determine the prevalence of LVO among acute ischemic stroke (AIS) patients presenting to Assiut University hospitals

Secondary Objectives:
- To describe clinical and radiological characteristics of LVO patients.
- To assess factors associated with LVO (age, sex, stroke severity, comorbidities).
Study Design
- Type: single center, prospective observational cross-sectional study
- Duration: 12-month recruitment period
- Setting: Assiut university hospitals, stroke unit.
Study Population

Inclusion Criteria:

Adults (≥18 years)
Diagnosed with acute ischemic stroke within 24 hours of symptom onset
Underwent vascular imaging (CTA or MRA) on admission

Exclusion Criteria:

Hemorrhagic stroke
Stroke mimics
Incomplete imaging data 4. Definitions

Large Vessel Occlusion (LVO) defined as occlusion in:

Intracranial ICA
M1 or proximal M2 segments of MCA
Basilar artery ± Optional: A1 6. Data Collection

Clinical Data:

Demographics (age, sex)
Risk factors (HTN, DM, AF, CAD, smoking)
NIHSS on admission and discharge mRS on admission and discharge
Onset-to-door time
Imaging modality used

Imaging Data:

Site of occlusion
ASPECTS (optional)
Collateral status (optional if available)

Hospital Data:

Facility type (public vs private)
Door-to-CT and door-to-CTA times 8. Analysis Plan
Primary: Prevalence of LVO = Number of LVO cases / Total AIS patients with vascular imaging
Subgroup analysis: By age group, sex, region, NIHSS
Secondary: Logistic regression to identify predictors of LVO

Detailed Description

Prevalence of Large Vessel Occlusion among acute ischemic stroke patients in Assiut University hospitals

Study Objectives

Primary Objective:

- To determine the prevalence of LVO among acute ischemic stroke (AIS) patients presenting to Assiut University hospitals

Secondary Objectives:
- To describe clinical and radiological characteristics of LVO patients.
- To assess factors associated with LVO (age, sex, stroke severity, comorbidities).
Study Design
- Type: single center, prospective observational cross-sectional study
- Duration: 12-month recruitment period
- Setting: Assiut university hospitals, stroke unit.
Study Population

Inclusion Criteria:

Adults (≥18 years)
Diagnosed with acute ischemic stroke within 24 hours of symptom onset
Underwent vascular imaging (CTA or MRA) on admission

Exclusion Criteria:

Hemorrhagic stroke
Stroke mimics
Incomplete imaging data 4. Definitions

Large Vessel Occlusion (LVO) defined as occlusion in:

Intracranial ICA
M1 or proximal M2 segments of MCA
Basilar artery ± Optional: A1 6. Data Collection

Clinical Data:

Demographics (age, sex)
Risk factors (HTN, DM, AF, CAD, smoking)
NIHSS on admission and discharge mRS on admission and discharge
Onset-to-door time
Imaging modality used

Imaging Data:

Site of occlusion
ASPECTS (optional)
Collateral status (optional if available)

Hospital Data:

Facility type (public vs private)
Door-to-CT and door-to-CTA times 8. Analysis Plan
Primary: Prevalence of LVO = Number of LVO cases / Total AIS patients with vascular imaging
Subgroup analysis: By age group, sex, region, NIHSS
Secondary: Logistic regression to identify predictors of LVO

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Yes

Target Follow-Up Duration

2 Days

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

No data available

No data is available for this block.

Enrollment

300Estimated

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
To determine the prevalence of LVO among acute ischemic stroke (AIS) patients presenting to Assiut University hospitals	Prevalence of LVO = Number of LVO cases / Total AIS patients with vascular imaging	12 months

Secondary Outcomes

Measure	Description	Time Frame
-To describe clinical and radiological characteristics of LVO patients. - To assess factors associated with LVO (age, sex, stroke severity, comorbidities).	Subgroup analysis: By age group, sex, region, NIHSS	12 months

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Adults (≥18 years)
Diagnosed with acute ischemic stroke within 24 hours of symptom onset
Underwent vascular imaging (CTA or MRA) on admission

Exclusion Criteria:

Hemorrhagic stroke
Stroke mimics
Incomplete imaging data

Accepts Healthy Volunteers

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

Not provided

Standard Ages

AdultOlder Adult

Study Population

Large Vessel Occlusion (LVO) defined as occlusion in:

Intracranial ICA
M1 or proximal M2 segments of MCA
Basilar artery ± Optional: A1

Clinical Data:

Demographics (age, sex)
Risk factors (HTN, DM, AF, CAD, smoking)
NIHSS on admission and discharge mRS on admission and discharge
Onset-to-door time
Imaging modality used

Imaging Data:

Site of occlusion
ASPECTS (optional)
Collateral status (optional if available)

Hospital Data:

Facility type (public vs private)
Door-to-CT and door-to-CTA times

Sampling Method

Non-Probability Sample

Contacts/Locations Module

Central Contacts

Name	Role	Phone	Extension	Email
Ahmed Nasr Professor of neurology, Professor	Contact	+201009949677		d_ahmednasr@yahoo.com

Overall Officials

Not provided

Locations

Not provided

Label	URL
Prevalence of cerebral Large Vessel Occlusion among acute ischemic stroke	View source

IPD Sharing Statement Module

Plan to Share IPD

Description

Financial issues

Types

Not provided

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided

Condition Browse Module

MeSH Terms

ID	Term
D000083242	Ischemic Stroke

Ancestor Terms

ID	Term
D020521	Stroke
D002561	Cerebrovascular Disorders
D001927	Brain Diseases
D002493	Central Nervous System Diseases

Browse Leaves

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Browse Branches

Not provided