investigate the molecular differences between primitive lung cancer and the metastatic site.

Inclusion Criteria:

• patients aged ≥18 years fit enough to tolerate the surgical operation;
• the operative risk is considered low based on respiratory reserve and cardiac assessment;
• the patient has clearly expressed willingness to adhere;
• availability of pathological material for tumor DNA extraction and NGS execution.

Exclusion Criteria:

• Women of childbearing age, pregnant or breastfeeding, or intending to become pregnant during the study.
• Any other illness, metabolic disorder, physical examination, or laboratory findings that constitute a contraindication to study participation.
• Recent or ongoing severe or clinically significant infection.

Patient diagnosed with NSCLC