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To evaluate the clinical efficacy of Weizmannia coagulans BC99 in young Chinese patients with exercise-induced muscle damage compared with placebo, and to explore its effects on inflammatory responses and intestinal microbiota.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo group | Placebo Comparator | 3g dose of milk protein concentrate/pack, 8 packs per day |
|
| BC99 group | Experimental | 3g dose of milk protein concentrate with 6×109 Colony Forming Unit (CFU) W. coagulans BC99/pack, 8 packs per day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Dietary Supplement | The experimental phase of this study lasts 12 weeks and each participant will have 3 visits (week 0, week 6, week 12) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pain evaluation | Visual analog scale (VAS) was used for assessing the pain level of muscle, ranging from 0 to 10 point (0 means no pain; 10 represent worst imaginable pain). VAS scores were recorded at 24h, 48h and 72h after the intense exercise work stress. | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Cortisol in plasma | This indicator was determined using commercially available assay kits (BYabscience, Nanjing, China). | 12 weeks |
| Peptide YY in plasma | This indicator was determined using commercially available assay kits (BYabscience, Nanjing, China). |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Wu Ying | Luoyang | Henan | 471000 | China |
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| BC99 | Dietary Supplement | The experimental phase of this study lasts 12 weeks and each participant will have 3 visits (week 0, week 6, week 12) |
|
| 12 weeks |