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Epithelial ovarian cancer (EOC) presents with peritoneal carcinomatosis (PC) at diagnosis in approximately two-thirds of cases. Diagnostic laparoscopy is pivotal to assess disease extent and to guide the choice between primary cytoreductive surgery (PCS) and neoadjuvant chemotherapy followed by interval cytoreductive surgery (ICS). The Predictive Index Value (PIV) provides a quantitative estimate of resectability, but it does not systematically capture qualitative intraoperative descriptors. Growing evidence suggests that macroscopic features (e.g., nodularity, plaques, omental cake, infiltrative vs expansile growth, margin definition, vascularization, and tissue retraction) may correlate with histotype and molecular profile, and possibly with chemosensitivity. However, surgeons' ability to recognize these visual patterns in a standardized manner has not been systematically investigated.
This cross-sectional survey will assess whether gynecologic oncologic surgeons managing PC can: distinguish malignant metastases from benign tumor-like lesions; associate morphologic patterns with tumor histotypes (type I vs type II EOC and ovarian metastases from other primaries); classify high-grade serous ovarian cancer (HGSOC) growth pattern as infiltrative vs exophytic/expansile; and infer molecular status from macroscopic appearance. The secondary objective is to compare accuracy and confidence between senior and junior surgeons.
Seventy to eighty surgeons will complete an online survey (Microsoft Forms) presenting anonymized laparoscopic images retrospectively selected from routinely recorded diagnostic-laparoscopy videos of 19 consented patients with advanced EOC and PC. Participants will classify each case using predefined categories and rate confidence on a 5-point Likert scale. Analyses will be primarily descriptive (counts/percentages); senior vs junior comparisons will use χ²/Fisher's exact tests for categorical variables and the Mann-Whitney U test for ordinal measures, as appropriate.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| VISUAL PC - SURVEY 2.0 | Other | Survey for surgeons in order to study their ability to recognize macroscopic features for selecting appropriate treatment strategies in patients with abdominal malignancies. |
| Measure | Description | Time Frame |
|---|---|---|
| Visual pattern of ovarian cancer | To assess the ability of gynecologic oncologic surgeons to visually recognize pathological and molecular features of peritoneal carcinomatosis in advanced ovarian cancer. | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Differences beetween senior and junior surgeons | To compare diagnostic accuracy between senior and junior surgeons. | 1 month |
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Inclusion Criteria:
Exclusion Criteria:
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Gynecologic oncologists with surgical experience in the management of ovarian cancer, both senior and young surgeons. A senior surgeon is a reference surgeon with a high level of expertise in ovarian cancer (OC) surgery, typically with years of independent surgical practice or holding a leadership or responsible role. The junior surgeon is a surgeon in advanced training or with a few years of experience in complex oncologic surgery for ovarian cancer.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anna Fagotti | Contact | +390630153502 | anna.fagotti@policlinicogemelli.it |
| Name | Affiliation | Role |
|---|---|---|
| Anna Fagotti | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Principal Investigator |
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| ID | Term |
|---|---|
| D010051 | Ovarian Neoplasms |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
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| D000291 |
| Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D000091662 | Genital Diseases |
| D004700 | Endocrine System Diseases |
| D006058 | Gonadal Disorders |