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This study evaluated the preemptive analgesic efficacy of Tapentadol in reducing peri operative analgesic requirements among patients undergoing breast cancer surgery.
A double blinded prospective RCT was conducted with 70 patients undergoing breast cancer surgery with 35 patients being studied with Administrated drug & other 35 as placebo. Intraoperative & postoperative morphine consumption was calculated and documented.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tapentadol | Active Comparator | Control drug (Tapentadol ) |
|
| Placebo | Placebo Comparator | Placebo sodium bicarbonate/ peppermint oil tablet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tapentadol | Drug | 75 mg oral tapentadol given 1 hour before surgery in control group and placebo tablet was given in Group B. Intraoperative and post operative morphine consumption and pain scores at 1,2,3,4 hours were calculated. |
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative and postoperative morphine consumption | During the course of surgery and up to 4 hours surgery Intraoperative and postoperative morphine consumption. | During the course of surgery and up to 4 hours surgery |
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Inclusion Criteria:
Exclusion Criteria:
Only females.
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| Name | Affiliation | Role |
|---|---|---|
| Dr. Allah Ditta Ashfaq | Shaukat Khanam Memorial Cancer Hospital & Research Centre LAHORE | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| SKMCH & RC Lahore | Lahore | Punjab Province | 042 | Pakistan |
No plan to share IPD. Due to confidentiality of patients data.
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Randomized control trial
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The patient and doctor providing anesthesia were blinded.
| Placebo | Other | Placebo tablet was given in group B. |
|
| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| D000077432 | Tapentadol |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
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