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| ID | Type | Description | Link |
|---|---|---|---|
| 22.03698.000189 | Other Identifier | Comité de protection des personnes (French Ethics committee) |
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| Name | Class |
|---|---|
| Centre National de la Recherche Scientifique, France | OTHER |
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Recent studies show that emotional states can be discriminated by physiological responses. This physiological regulation results from the action of enzymes and hormones that represent the activity of the autonomic nervous system. The measurement of specific biomarkers, using non-invasive biological tests in saliva, would therefore provide physiological data on an individual's emotional state in response to stimuli, particularly olfactory stimuli.
Recent studies show that emotional states (positive and negative) can be discriminated by physiological responses. This physiological regulation stems from the action of enzymes and hormones that represent the activity of the autonomic nervous system. The measurement of specific biomarkers (enzymes, hormones), using non-invasive biological tests in saliva, would therefore provide physiological data on an individual's emotional state (Giacomello et al. 2020) in response to stimuli, particularly olfactory stimuli.
The aim of the proposed research is to identify and measure a signature of molecular biomarkers in saliva, linked to emotions following one or more olfactory stimuli (e.g. cortisol and alpha-amylase concentration increase after stimulation).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bras S Fragrance then placebo | Subjects will be subjected successively to fragrance and placebo stimulation. |
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| Bras P Placebo then fragrance | Subjects will be subjected successively to placebo and fragrance stimulation. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Identication and measurement of a molecular biomarkers signature | Other | Levels of the biomarkers of interest (DHEA, pg/mL; Oxytocin, pg/mL; Cortisol, pg/mL; Alpha Amylase, U/mL) will be measured in the saliva of participating subjects by enzymatic assay methods or ELISA-type methods performed using commercial kits. |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate variations | Evaluate variations in several molecular biomarkers in saliva following fragrance stimulus/stimuli that may be linked to an emotionnal response (positive or negative). | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Identify a molecular biomarker signature | Identify a molecular biomarker signature in saliva following fragrance stimulus or stimuli. | 2 years |
| Evaluate basal values of biomarkers | Evaluate basal values of biomarkers composing the signature under normal, unstimulated conditions (intra-individual, inter-individual variations, circadian rhythm, age, gender...). |
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Inclusion Criteria:
Exclusion Criteria:
Non specific inclusion criteria:
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The population for this study will consist of healthy volunteers who meet the eligibility criteria.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wendpouiré A OUEDRAOGO, Msc | Contact | +33 (0) 467 047 481 | alimata.ouedraogo@sys2diag.cnrs.fr |
| Name | Affiliation | Role |
|---|---|---|
| Laurence MOLINA, Phd | Sys2Diag | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| SYS2DIAG - UMR9005 CNRS/ALCEN, Montpellier, 34184 | Recruiting | Montpellier | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32957066 | Background | Giacomello G, Scholten A, Parr MK. Current methods for stress marker detection in saliva. J Pharm Biomed Anal. 2020 Nov 30;191:113604. doi: 10.1016/j.jpba.2020.113604. Epub 2020 Sep 6. |
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Saliva
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| 3 years |
| Evaluate signature dynamics | Evaluate signature dynamics after stimulation | 1 year |
| Establish correlations between biomarker signatures and emotion ratings | Establish correlations between biomarker signatures and emotion ratings based on other criteria, such as questionnaires. | 3 years |
| Compare biomarker signatures | Compare biomarker signatures in response to different fragrance stimuli. | 2 years |