The purpose of this study is to demonstrate the efficacy of early continuous intravenous infusion of hypertonic saline solution (HSS) to improve survival and independence in daily life activities (at 6 months) of patients with traumatic brain injury at high risk of intracranial hypertension.

Inclusion Criteria:

• Patient admitted to intensive care unit
• Traumatic brain injury with Glasgow Coma Scale ≤ 12
• Intracranial pressure (ICP) monitoring based on the attending physician's clinical judgment, in accordance with guidelines or clinical/radiological signs considered at risk of intracranial hypertension
• Inclusion during the first 12 hours after Intracranial pressure monitoring placement
• Informed and signed consent
• National health insurance

Exclusion Criteria:

• Glasgow Coma Scale (score = 3) and persistent abnormal pupillaryreactivity despite urgent therapy
• Associated cervical spinal cord injury
• Imminent death and do-not-resuscitate orders
• Coma secondary to cardiac arrest
• Pregnancy (serum or urine test performed in routine care)
• Severe Cardiac insufficiency
• Severe chronic renal insufficiency
• Severe hepatic insufficiency: patient presenting with oedemato-ascitic decompensation of liver cirrhosis or patient with Child-Pugh class C cirrhosis
• High risk of follow-up difficulties after ICU discharge
• Patients under court protection
• Patient who does not speak French