Sensitivity to Ovarian Hormones and Depression in Adolescents

Sensitivity to Ovarian Hormones and Depression in Adolescents

The goal of this observational study is to learn about the relationship between changes in ovarian hormones (estrogen and progesterone) and adolescent depression. The main question it aims to answer is:

Can we identify a subset adolescents assigned female at birth with a history of depression who are particularly sensitive to changes in ovarian hormones? Participants will be monitoring daily absolute ovarian hormone levels at home using the Mira Analyzer and answer online survey questions about their mental health for 90 days.

Inclusion Criteria:

• Assigned female at birth, at least 1 year post-menarche, naturally cycling, history of depression or symptoms of depression, and able to read and write in English.

Exclusion Criteria:

• Pregnant or taking any hormonal or cycle altering medications/devices.