Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of this work is to assess the benefit of coenzyme Q10 supplementation, in addition to standard antibiotic and other supportive therapy, in the management of hospitalized children with community acquired pneumonia
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 60 children with community acquired pneumonia will receive oral coenzymeQ10 | Experimental |
| |
| 60 children with community acquired pneumonia with the standard pneumonia treatment. | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| oral coenzymeQ10 | Drug | 60 children with community acquired pneumonia will receive oral coenzymeQ10 in capsule form at a dose of 100-200 mg/kg/day, as adjunct therapy to the usual pneumonia treatment till the recovery of the disease. |
| Measure | Description | Time Frame |
|---|---|---|
| Normalization of respiratory rate | 3 days | |
| Normalization of temperature | 3 days | |
| Normalization of oxygen saturation | 3 days | |
| Normalization of Feeding Behavior Assessed by Oral Intake Tolerance | Normalization of feeding refusal will be assessed by evaluating the child's ability to tolerate age-appropriate oral feeding without refusal over a 3-day observation period. | 3 days |
| Serum C-Reactive Protein (CRP) Level | Blood samples will be collected, and CRP concentration will be expressed in milligrams per liter (mg/L). | 5 days |
| Serum Lactate Dehydrogenase (LDH) Level | LDH concentration will be reported in units per liter (U/L) from venous blood samples. | 5 days |
| Prognostic Nutritional Index | 5 days | |
| Systemic Immune-Inflammation Index | 5 days | |
| Serum C-Reactive Protein to Albumin Ratio (CRP/Albumin Ratio) | The serum C-reactive protein to albumin ratio (CRP/albumin ratio) will be calculated as a single composite outcome measure using laboratory values obtained from the same blood sample. |
| Measure | Description | Time Frame |
|---|---|---|
| Length of hospital stay | 10-21 days | |
| Number of Participants Requiring Surgical Intervention | This outcome measures whether a participant undergoes any surgical intervention related to the study condition during the follow-up period. Surgical intervention is defined as any operative procedure performed under general or regional anesthesia, as documented in the medical record. The outcome will be recorded as a binary variable (Yes/No) for each participant and summarized as the number and proportion of participants requiring surgical intervention. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmed Elniny Lecturer of Pediatrics, MD | Contact | 01002219783 | Ahmedelniny8@gmail.com |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tanta University | Tanta | Gharbia Governorate | 37515 | Egypt |
Not provided
| ID | Term |
|---|---|
| D000098968 | Community-Acquired Pneumonia |
| ID | Term |
|---|---|
| D017714 | Community-Acquired Infections |
| D007239 | Infections |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| 5 days |
| Time of clinical stability | 3-5 days |
| 21-30 days |
| D012140 |
| Respiratory Tract Diseases |