The purpose of this study is to learn how the study medicine PF-07328948 is processed by the body and how safe and tolerable it is in adults with different levels of kidney function.

The study will include participants who:

• Are aged 18 to 80 years.
• Either have normal kidney function or long-term reduced kidney function (moderate or severe).
• Have a BMI (body mass index) of 17.5 to 40 kilogram per meter squared, inclusive, and a total body weight of more than or equal to 45 kilograms or 99 pounds.

All participants will receive a single dose of PF-07328948 as a tablet taken by mouth. Participants will stay at a clinical research unit for about 6 days to receive the study medicine and undergo safety checks. Total participation lasts up to 64 days, including screening, inpatient stay, and a follow-up call.

The study is not randomized or blinded, meaning all participants and study staff know which treatment is being given. Group assignment is based on kidney function tests done during screening. The results will help researchers understand how reduced kidney function affects the way PF-07328948 works in the body.

Inclusion Criteria:

• Male or female of nonchildbearing potential, between the ages of 18 and 80 years, at the screening visit.

• BMI of 17.5 to 40.0 kg/m2 (inclusive), and a total body weight ≥45 kg (99 lbs).

• Stable renal function, defined as ≤25% difference between 2 measurements of eGFR.

• Group 1 only: at screening, no clinically relevant abnormalities identified by a detailed medical history, physical exam, including blood pressure and pulse rate measurement, ECG and clinical laboratory tests.

• Group 1 only: normal renal function (mean eGFR ≥90 mL/min) based on an average of measures from the screening visits.

• Groups 2 & 3 only: good general health considered acceptable with the expected health status of individuals with chronic renal impairment.

• Groups 2 & 3 only: chronic renal impairment, defined by the following mean eGFR criteria (based on screening visits):

  • Severe RI: 15 ≤ mean eGFR <30 mL/min, not requiring hemodialysis.
  • Moderate RI: 30 ≤ mean eGFR <60 mL/min.

Exclusion Criteria:

• Any condition possibly affecting drug absorption.
• At screening, a positive result for HIV antibodies.
• History of renal, liver, or heart transplantation.
• Urinary incontinence without catheterization.
• Evidence of a prothrombotic state, including history of deep vein thrombosis, pulmonary embolism, or arterial thrombosis, or known genetic predisposition.
• Use of an investigational product within 30 days or 5 half-lives (whichever longer).
• A positive urine drug test or breath alcohol test at screening or admission to study clinic.
• Group 1 only: evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, or allergic disease.
• Group 1 only: screening ECG demonstrating QTcF interval >450 ms or a QRS interval >120 ms.
• Group 1 only: screening seated systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg
• Group 2 & 3 only: presence of acute renal disease
• Group 2 & 3 only: requiring dialysis or anticipated need for dialysis
• Group 2 & 3 only: listed for solid organ transplantation
• Groups 2 & 3 only: persistent severe, uncontrolled hypertension at screening, admission to study clinic, or pre-dose on Day 1.
• Groups 2 & 3 only: screening ECG demonstrating a QTcF interval >470 ms or a QRS interval >120 ms.
• Groups 2 & 3 only: unstable medical conditions or comorbidities that would interfere with study participation

Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical\_trials/trial\_data\_and\_results/data\_requests.