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The goal of this prospective observational study is to compare the effectiveness of different postoperative analgesic techniques in patients undergoing major abdominal surgery for gynecologic oncology.
The main question is whether the combination of TAP block with Quadratus Lumborum Block (QLB) or Rectus Sheath Block (RSB) provides superior pain relief compared to TAP block alone.
All blocks were performed as part of routine clinical anesthesia practice according to the attending anesthesiologist's judgment. No randomization, allocation, or study-directed intervention was performed.
Patients were classified into three groups based on the block type they received during standard care:
Group 1: TAP Block Only
Group 2: TAP + QLB Combination
Group 3: TAP + RSB Combination
Postoperative data, including pain scores (VAS), opioid consumption, sedation level, heart rate, blood pressure, nausea/vomiting, and length of hospital stay, were collected prospectively.
The study aims to determine which block combination provides the best postoperative pain control and recovery profile in patients undergoing gynecologic oncology surgery.
This study is a prospective observational research designed to evaluate the postoperative analgesic effectiveness of different combinations of fascial plane blocks in patients undergoing gynecologic oncology surgery.
All blocks (Transversus Abdominis Plane [TAP] block, Quadratus Lumborum Block [QLB], and Rectus Sheath Block [RSB]) were performed as part of routine clinical anesthesia practice according to the attending anesthesiologist's preference.
No intervention, randomization, or protocol-directed procedure was applied for research purposes. After data collection, patients were classified into three groups based on the block type they had received in standard care:
TAP block only
TAP + QLB combination
TAP + RSB combination
The study prospectively compared postoperative pain scores (VAS), opioid consumption, time to mobilization, bowel function recovery, and length of hospital stay among these groups to determine the most effective analgesic strategy within routine practice.
This observational design reflects real-world anesthesia management and does not involve any experimental or interventional component.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1: TAP Block Only Group | Patients who received only Transversus Abdominis Plane (TAP) block as part of routine anesthesia practice. No additional regional block was performed. |
| |
| Group 2: TAP + QLB Combination | Patients who received both TAP block and Quadratus Lumborum Block (QLB) as part of standard clinical anesthesia management. |
| |
| Group 3: TAP + RSB Combination | Patients who received both TAP block and Rectus Sheath Block (RSB) as part of standard clinical anesthesia management. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Group 1:The Transversus Abdominis Plane (TAP) block | Other | Patients who received only Transversus Abdominis Plane (TAP) block as part of routine clinical anesthesia practice. No study-assigned intervention or randomization was performed. Data were collected prospectively from standard anesthesia records. |
| Measure | Description | Time Frame |
|---|---|---|
| Total Morphine Consumption | Total amount of morphine (mg) administered to the patient within the first 24 hours after surgery for postoperative analgesia. Morphine use will be recorded from patient-controlled analgesia (PCA) device data or medical records. | Within 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pain intensity (VAS score) | Pain intensity will be evaluated using the Visual Analog Scale (VAS; 0 = no pain, 10 = worst pain) at 0 min, 15 min, 2 hr, 6 hr, 12 hr, and 24 hr postoperatively. | 0-24 hours postoperatively; VAS score (0-10) |
| Incidence of postoperative nausea and vomiting |
| Measure | Description | Time Frame |
|---|---|---|
| 1.Sedation Level (Ramsey Sedation Score) | Sedation level evaluated using the Ramsey Sedation Scale at multiple postoperative time points. | 0-24 hours after surgery |
Inclusion Criteria
Exclusion Criteria
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The study population consists of adult female patients who are undergoing elective major abdominal surgery due to gynecologic cancer (e.g., endometrial cancer, ovarian cancer, debulking surgery). Participants will be aged 18 years and older, and only those with ASA I-IV status who are deemed fit for surgery will be included.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital | Ankara | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38336613 | Result | Yu S, Wen Y, Lin J, Yang J, He Y, Zuo Y. Combined rectus sheath block with transverse abdominis plane block by one puncture for analgesia after laparoscopic upper abdominal surgery: a randomized controlled prospective study. BMC Anesthesiol. 2024 Feb 9;24(1):58. doi: 10.1186/s12871-024-02444-6. | |
| 31973700 | Result |
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|
| Group 2: TAP Block + Quadratus Lumborum Block (QLB) | Other | Patients who received TAP block combined with Quadratus Lumborum Block (QLB) during routine anesthesia management. This block combination was chosen by the attending anesthesiologist as part of standard care, not assigned by the study. |
|
| Group 3: TAP Block + Rectus Sheath Block (RSB) | Other | Patients who received TAP block combined with Rectus Sheath Block (RSB) as part of routine anesthesia practice. The block technique was performed according to clinical judgment, not as part of a study intervention. |
|
Number of patients experiencing postoperative nausea and/or vomiting within the first 24 hours. |
| Time Frame: 0-24 hours postoperatively |
| Time to first gas or stool passage | Time from the end of surgery to the first postoperative bowel movement or passage of gas. | From the end of surgery up to postoperative 72 hours |
| Time to mobilization | Time from the end of surgery to the first postoperative ambulation. | From the end of surgery up to postoperative 72 hours |
| Time to oral intake | Time from the end of surgery to the first postoperative oral feeding | From the end of surgery up to postoperative 72 hours |
| Length of hospital stay | Total duration of hospitalization after surgery. | From surgery to hospital discharge (up to 10 days) Unit of Measure:Days |
| Intensive care unit (ICU) length of stay | Total duration of postoperative stay in the intensive care unit. | From surgery to hospital discharge (up to 3 days) Unit of Measure: Days |
| Zhu JL, Wang XT, Gong J, Sun HB, Zhao XQ, Gao W. The combination of transversus abdominis plane block and rectus sheath block reduced postoperative pain after splenectomy: a randomized trial. BMC Anesthesiol. 2020 Jan 23;20(1):22. doi: 10.1186/s12871-020-0941-1. |
| 29536008 | Result | Akerman M, Pejcic N, Velickovic I. A Review of the Quadratus Lumborum Block and ERAS. Front Med (Lausanne). 2018 Feb 26;5:44. doi: 10.3389/fmed.2018.00044. eCollection 2018. |
| ID | Term |
|---|---|
| D003766 | Dental Occlusion |
| ID | Term |
|---|---|
| D003813 | Dentistry |
| D009063 | Dental Physiological Phenomena |
| D055688 | Digestive System and Oral Physiological Phenomena |
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