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| ID | Type | Description | Link |
|---|---|---|---|
| 2025/1365 | Registry Identifier | Mahidol University Multi-faculty Cooperative IRB Review |
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This project aims to study the effect of exercise in the obesity/overweight on the changes of physical fitness and blood components. This will provide novel knowledge for medical staffs, researchers, or companies developing alternative strategies for treating obesity/overweight, including drug development and health promotion project to delay or prevent the onset of the disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High-intensity interval training exercise | Experimental | High-intensity interval training exercise 3 days per week for 6 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High-intensity interval training exercise on treadmill | Device | High-intensity interval training exercise using 65% to 80% of heart rate max |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood component assessment | Participant's blood components, e.g. extracellular vesicles, will be investigated by cell assays and proteomic analysis | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program within 1 hour) |
| Foot pressure distribution | Foot pressure distribution will be measured using a treadmill (Zebris FDM-T Treadmill System, zebris Medical GmbH, Germany) | 8 times: Day 1 (Before and after HIIT program), Day 4-7 (after HIIT program only), Day 18 (Before and after HIIT program) |
| Facial and abdominal fat thickness measurement | Facial and abdominal fat thickness and characteristics will be pictured and analyzed using ultrasound imaging | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) |
| VO2max | VO2max parameter (ml/kg/min) will be examined using Cardio Pulmonary Exercise Test | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) |
| Body composition | Body composition (%) will be measured by bioelectrical impedance analysis. | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) |
| Heart rate | Heart rate (beat/min) will be measured by pulse oximeters | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) |
| Grip strength |
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Inclusion Criteria:
Male or female individuals aged between 25-45 years
Thai nationality
Ability to walk or perform daily activities independently, without the use of an assistive device
Body mass index (BMI) between 25-35 kg/m²
Low physical activity levels or sedentary lifestyle based on the World Health Organization 2020
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Onaong Mee-inta, Ph.D. | Contact | (66)619922941 | onanong.mee@mahidol.ac.th | |
| Phunsuk Kantha, Ph.D. | Contact | (66)932951646 | phunsuk.kan@mahidol.ac.th |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital | Recruiting | Mueang Samut Prakan | 10540 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22854902 | Background | Gremeaux V, Drigny J, Nigam A, Juneau M, Guilbeault V, Latour E, Gayda M. Long-term lifestyle intervention with optimized high-intensity interval training improves body composition, cardiometabolic risk, and exercise parameters in patients with abdominal obesity. Am J Phys Med Rehabil. 2012 Nov;91(11):941-50. doi: 10.1097/PHM.0b013e3182643ce0. | |
| 32492705 |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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|
Grip strength (kg) will be measured by hand grip dynamometer |
| Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) |
| Leg strength | Leg strength (kg) will be measured by back-leg-chest dynamometer | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) |
| Body weight | Body weight (kg) will be measured by weighing scale | Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program) |
| Body height | Body height (cm) will be measured by stadiometer | Pre-training (Day 1 before HIIT program) |
| Ryan BJ, Schleh MW, Ahn C, Ludzki AC, Gillen JB, Varshney P, Van Pelt DW, Pitchford LM, Chenevert TL, Gioscia-Ryan RA, Howton SM, Rode T, Hummel SL, Burant CF, Little JP, Horowitz JF. Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults. J Clin Endocrinol Metab. 2020 Aug 1;105(8):e2941-59. doi: 10.1210/clinem/dgaa345. |
| 29071102 | Background | Turk Y, Theel W, Kasteleyn MJ, Franssen FME, Hiemstra PS, Rudolphus A, Taube C, Braunstahl GJ. High intensity training in obesity: a Meta-analysis. Obes Sci Pract. 2017 May 29;3(3):258-271. doi: 10.1002/osp4.109. eCollection 2017 Sep. |
| 28579942 | Background | He XF, Liu DX, Zhang Q, Liang FY, Dai GY, Zeng JS, Pei Z, Xu GQ, Lan Y. Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice. Front Mol Neurosci. 2017 May 19;10:144. doi: 10.3389/fnmol.2017.00144. eCollection 2017. |
| 26077718 | Background | Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med. 2015 Jun 29;212(7):991-9. doi: 10.1084/jem.20142290. Epub 2015 Jun 15. |
| 26030524 | Background | Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015 Jul 16;523(7560):337-41. doi: 10.1038/nature14432. Epub 2015 Jun 1. |
| 25399804 | Background | Secker GA, Harvey NL. VEGFR signaling during lymphatic vascular development: From progenitor cells to functional vessels. Dev Dyn. 2015 Mar;244(3):323-31. doi: 10.1002/dvdy.24227. Epub 2014 Dec 4. |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |