Target-Controlled Infusion and Postoperative Neurocognitive Outcomes in Geriatric Patients

The Effect of Target-Controlled Infusion (TCI) on Neurocognitive Functions in Postoperative Sedoanalgesia Management in Geriatric Patients Undergoing Major Surgery

This prospective observational study aims to evaluate the effects of target-controlled infusion (TCI) on postoperative neurocognitive function in geriatric patients undergoing major non-cardiac surgery. Elderly patients are at increased risk of postoperative cognitive dysfunction due to physiological changes and anesthesia-related factors. In this study, sedation management with TCI will be compared to manual infusion. Neurocognitive function will be assessed at multiple time points using the Mini-Mental State Examination (MMSE), and sedation levels will be monitored with the Bispectral Index (BIS) and the Richmond Agitation-Sedation Scale (RASS). The study aims to provide insights into safer sedation practices and improved cognitive outcomes in elderly surgical patients.

Inclusion Criteria:

• Patients aged 65 years and older
• Undergoing noncardiac, nonneurosurgical major surgery under general anesthesia
• Monitored postoperatively in the intensive care unit
• Provided informed consent to participate in the study

Exclusion Criteria:

• Cardiac or neurosurgical procedures
• Patients younger than 65 years
• Glasgow Coma Scale < 8
• No informed consent
• Body mass index (BMI) > 35
• Communication difficulties preventing cognitive testing
• Known allergy to study medications