Clinical and Radiographic Assessment of Efficacy of Modified Minimally Invasive SurgicalTechnique (M-MIST) Alone and Combined With Enamel Matrix Proteins and Ox-derived Bone Graft in the Treatment of Single Bone Defects Between Teeth.

Clinical and Tomographic Efficacy of the Modified Minimally Invasive Surgical Technique (M-MIST) Alone and Combined With Enamel Matrix Derivative (EMD) and Bone Mineral Derived Xenograft (BMDX), in the Treatment of Isolated, Inter-dental Intra-bony Defects

This study was performed to investigate the adjunctive clinical benefit of the application of enamel matric derivatives and xenograft with the modified minimally invasive surgical technique in the treatment of isolated intrabony defects in periodontally compromised subjects.

Inclusion Criteria:

• at least one site associated with an intrabony defect of ≥3 mm involving predominantly the interdental space of the tooth
• patients with optimal compliance

Exclusion Criteria:

• Patients with uncontrolled or poorly controlled diabetes
• history of long-term use of medications
• allergic to medications
• pregnant or lactating women
• smokers/users of other tobacco products