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The number of atrial fibrillation (AF) patients in China is approximately 32.76 million, with a prevalence rate of 2.3%. AF is associated with severe outcomes such as stroke and heart failure. Metabolic disorders (e.g., obesity, diabetes mellitus, dyslipidemia) are closely linked to the onset and prognosis of AF. However, the epidemiological characteristics and disease burden of AF combined with metabolic disorders in China remain unclear. Additionally, the impact of complex multi-dimensional metabolic disorders on AF prognosis requires further investigation, and current clinical guidelines lack targeted management recommendations for this population.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No metabolic disorder | |||
| Single metabolic disorder | |||
| Complex metabolic disorder (≥2 types) |
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| Measure | Description | Time Frame |
|---|---|---|
| Major Adverse Cardiovascular Events (MACE) | Major Adverse Cardiovascular Events (MACE) - Composite outcome including the following components, all assessed during the entire follow-up period:
| From enrollment to the end of follow-up at 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular mortality | Defined as death caused by cardiovascular diseases (including myocardial infarction, heart failure, stroke, arrhythmia, etc.), determined by review of death certificate, autopsy report or clinical records by the endpoint adjudication committee. | From enrollment to the end of follow-up at 5 years |
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Inclusion Criteria
Exclusion Criteria
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Meets the diagnostic criteria for AF: single-lead electrocardiogram (ECG) ≥ 30 seconds or 12-lead ECG ≥ 10 seconds, with disappearance of P waves, presence of fibrillatory (f) waves, and absolute irregularity of RR intervals.
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| D008659 | Metabolic Diseases |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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peripheral blood
| Cognitive impairment assessed by the Mini-Mental State Examination (MMSE) scale |
Defined as a score ≤23 on the Mini-Mental State Examination (MMSE) scale at follow-up visits, with cognitive decline confirmed by a neuropsychological assessment panel if necessary (MMSE covers orientation, memory, attention, calculation, language and motor functions). |
| From enrollment to the end of follow-up at 5 years |
| Quality of life: Assessed by the Atrial Fibrillation Effect on Quality of Life (AFEQT) questionnaire | Assessed by the Atrial Fibrillation Effect on Quality of Life (AFEQT) questionnaire at baseline, 6 months, 12 months and annually thereafter; total score ranges from 0 (worst quality of life) to 100 (best quality of life), with subscores for symptoms, activity, treatment concern and quality of life reported separately. | From enrollment to the end of follow-up at 5 years |
| Atrial fibrillation (AF) treated with catheter ablation for 2 or more times | Defined as receiving a second or subsequent catheter ablation procedure due to AF recurrence after the initial ablation, documented by interventional procedure records. | From enrollment to the end of follow-up at 5 years |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D009750 | Nutritional and Metabolic Diseases |