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The present study was a double-blind, randomised, controlled clinical trial with a parallel design, comparing the coronally advanced flap (CAF) with platelet-rich fibrin (PRF) and chorion membrane (CM) for the treatment of isolated gingival recession defects. A total of 50 patients were randomly divided into; Experimental site A: Twenty five sites were treated with coronally advanced flap (CAF) and platelet-rich fibrin (PRF) membrane; Experimental site B: Twenty five sites were treated with coronally advanced flap (CAF) and chorion membrane (CM)The study was conducted in accordance with the Declaration of Helsinki, protocol was developed and ethical clearance was obtained from the Institutional Ethics Committee, Institute of Dental Sciences, Bareilly, India [IDS/ETHCC/14/08]. As per protocol, a study was conducted in five phases: (1) initial screening; (2) initial therapy and clinical measurements; (3) surgical therapy; (4) maintenance phase; and (5) post-operative evaluation after 1 month, 3 months, and 6 months.
Platelet-rich fibrin (PRF), a second-generation platelet concentrate, accelerates soft and hard tissue regeneration. Chorion membrane, of fetal origin, has wound-modulating properties. This study aimed to evaluate and compare the clinical outcomes of PRF and chorion membrane in treating isolated Miller's Class I or II gingival recession defects. Fifty recession defects in 50 patients were randomly treated with a coronally advanced flap (CAF) and PRF membrane (site A, n = 25) or CAF with chorion membrane (site B, n = 25). Clinical parameters recorded at baseline, 1, 3, and 6 months included recession depth (RD), recession width (RW), clinical attachment level (CAL), width of keratinised gingiva (WKG), plaque index (PI), gingival index (GI), and gingival biotype. Statistical analysis compared outcomes across follow-up intervals. At six months, both groups demonstrated significant improvements in RD, RW, CAL, WKG, PI, and GI compared with baseline. Mean percentage root coverage was 86.76 ± 13.76 in the PRF group and 82.89 ± 15.65 in the chorion group, with no statistically significant difference between them. Sites with an initial thin biotype showed conversion to a thick biotype in both groups. Both PRF and chorion membrane demonstrated predictable effectiveness for managing isolated recession defects, with comparable outcomes. Longitudinal studies are needed to confirm these findings.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental site A: patient were treated with coronally advanced flap and PRF | Experimental | Twenty five sites in each of 25 patient were treated with coronally advanced flap (CAF) and platelet-rich fibrin (PRF) membrane; |
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| Experimental site B: patient were treated with coronally advanced flap (CAF) and CM | Experimental | Twenty five sites in each of other 25 patient were treated with coronally advanced flap (CAF) and chorion membrane (CM) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coronally advanced flap (CAF) with platelet-rich fibrin (PRF) | Procedure | Description: After achieving adequate anaesthesia with 2% lignocaine (1:80,000 adrenaline), an intrasulcular incision was made on the buccal aspect of the involved teeth. Two horizontal incisions were placed from the mesial and distal angles to the papillae at the CEJ, without involving adjacent gingival margins. From their ends, two bevelled, slightly divergent oblique incisions were extended beyond the mucogingival junction, creating a trapezoidal flap. A full-thickness flap was raised up to the MGJ, followed by split-thickness dissection apically, with periosteal release to allow passive coronal mobilization. Adequate mobilization was defined as the flap margin reaching passively coronal to the CEJ. The coronal papilla soft tissue was de-epithelialized to prepare connective tissue beds for suturing of the coronally advanced flap. At the recipient site, the prepared PRF membrane was placed over the denuded root surfaces. |
| Measure | Description | Time Frame |
|---|---|---|
| Recession depth (RD) | Measured from the cemento-enamel junction (CEJ) to the most apical extension of the gingival margin | Baseline, prior to surgery and at 1 month, 3 months and 6 months follow-up visits |
| Recession width (RW) | Measured between mesial and distal papillae across the buccal surface at the CEJ level | Baseline, prior to surgery and at 1 month, 3 months and 6 months follow-up visits |
| Clinical attachment level (CAL) | Measured from the CEJ to the bottom of the gingival sulcus; | Baseline, prior to surgery and at 1 month, 3 months and 6 months follow-up visits: |
| Width of keratinized gingiva (WKG) | Measured from the gingival margin to the mucogingival junction (MGJ) | Baseline, prior to surgery and at 1 month, 3 months and 6 months follow-up visits |
| Assessment of gingival biotype | Evaluated based on the transparency of the probe through the gingival margin while probing the sulcus at the midfacial aspect of teeth | Baseline, prior to surgery and at 1 month, 3 months and 6 months follow-up visits |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Shatyajit Naik, MDS | Institute of Dental Sciences, Bareilly, Uttar Pradesh, India | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Periodontics and implantology , Institute of Dental sciences, Bareilly, Uttar Pradesh, India | Bareilly | Uttar Pradesh | India |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33565266 | Background | Bertl K, Spineli LM, Mohandis K, Stavropoulos A. Root coverage stability: A systematic overview of controlled clinical trials with at least 5 years of follow-up. Clin Exp Dent Res. 2021 Oct;7(5):692-710. doi: 10.1002/cre2.395. Epub 2021 Feb 9. | |
| 18584934 | Background | Chambrone L, Chambrone D, Pustiglioni FE, Chambrone LA, Lima LA. Can subepithelial connective tissue grafts be considered the gold standard procedure in the treatment of Miller Class I and II recession-type defects? J Dent. 2008 Sep;36(9):659-71. doi: 10.1016/j.jdent.2008.05.007. Epub 2008 Jun 26. |
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the clinical mesurement values were shared for statistical analysis
it is completed
statician will acess the information for statistical analysis
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP_ICF | Yes | Yes | Yes | Study Protocol, Statistical Analysis Plan, and Informed Consent Form | Dec 4, 2015 |
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| A similar surgical procedure was followed for the recipient bed preparation similar to that for the PRF membrane. A chorion membrane (Tissue bank, Tata Memorial Hospital, Mumbai, Maharashtra, India) o | Procedure |
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| 41545633 | Derived | Tripathi B, Manjunath RGS, Garg J, Gokhale ST, Nagate RR, Nishant K, Al-Qahtani SM, Al Magbol M, Tikare S, Chaturvedi M, Al-Qarni MA, Elagib MFA, Javali MA, Chaturvedi S. PRF membrane vs. chorion membrane with coronally advanced flap: a clinical study on gingival recession. Odontology. 2026 Jan 17. doi: 10.1007/s10266-026-01312-8. Online ahead of print. |
| Dec 19, 2025 |
| Prot_SAP_ICF_000.pdf |
| ID | Term |
|---|---|
| D005889 | Gingival Recession |
| ID | Term |
|---|---|
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D055093 | Periodontal Atrophy |
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| ID | Term |
|---|---|
| D014015 | Tissue Banks |
| ID | Term |
|---|---|
| D018070 | Biological Specimen Banks |
| D006268 | Health Facilities |
| D005159 | Health Care Facilities Workforce and Services |
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