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The hypothesis of the present study is that restoring nasal stimulation alleviates dyspnea and improves respiratory drive. The aim of this study is to compare three non-pharmacological approaches designed to restore nasal stimulation (continuous nasal airflow, nasal sprays, and facial airflow) in tracheotomized patients dependent on mechanical ventilation.
Nasal stimulation is generated by breathing, which enables olfaction and helps to rhythm brain activity. The loss of nasal stimulation in tracheotomized patients who are dependent on mechanical ventilation may negatively affect respiratory drive and contribute to dyspnea. Restoring nasal airflow therefore emerges as an attractive non-pharmacological approach to treat dyspnea in patients undergoing mechanical ventilation weaning.
The hypothesis of the present study is that restoring nasal stimulation alleviates dyspnea and improves respiratory drive. The aim of this study is to compare three non-pharmacological approaches designed to restore nasal stimulation (continuous nasal airflow, nasal sprays, and facial airflow) in tracheotomized patients dependent on mechanical ventilation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients ventilated | Experimental | Baseline ventilator settings under pressure support |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Baseline | Procedure | patient ventilated through the tracheostomy with initial ventilator settings |
|
| Measure | Description | Time Frame |
|---|---|---|
| Dyspnea | visual analogical scale | minute 20 |
| Measure | Description | Time Frame |
|---|---|---|
| airway occlusion pressure | visual analogical scale | minute 20 |
| end expiratory occlusion pressure | visual analogical scale | minute 20 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Martin DRES, MD PhD | Contact | +33142167809 | martin.dres@aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| Martin Dres, MD PhD | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
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The procedures carried out with the French data privacy authority (CNIL, Commission nationale de l'informatique et des libertés) do not provide for the transmission of the database, nor do the information and consent documents signed by the patients.
Consultation by the editorial board or interested researchers of individual participant data that underlie the results reported in the article after deidentification may nevertheless be considered, subject to prior determination of the terms and conditions of such consultation and in respect for compliance with the applicable regulations
Beginning 3 months and ending 3 years following article publication. Requests out of these time frame can also be submitted to the sponsor
Researchers who provide a methodologically sound proposal.
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| ID | Term |
|---|---|
| C074807 | BaseLine dental cement |
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| Installation of high flow humidified air cannula | Procedure | Installation of high flow humidified air cannula with inspired oxygen fraction (FiO2) 21% |
|
| Nasal air puffs | Procedure | Nasal air puffs synchronized with the inspiratory time of the ventilator |
|
| propeller fan (FAN) | Procedure | Stand-alone fan at the bedside directed toward the face of the patient |
|
| respiratory electromyogram (EMG) | visual analogical scale | minute 20 |
| tolerance | visual analogical scale | minute 20 |