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Following oncolytic virus (OV) administration, the host immune response is initiated immediately and evolves dynamically. However, in clinical OV therapy, it is virtually impossible to capture these immune events in real time. To address this gap, the principal investigator conducted a high-resolution immune monitoring study in a healthy volunteer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| OV Treated healthy arm | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| OTS-412 | Biological | After hospitalization, OTS-412 was infused for one hour. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in ANC(absolute neutrophil count) over time | 4 hour, 8 hour, 20 hour, 24 hour, Day 2, Day 5, Day 8, Day 16 | |
| Changes in lymphocytes count over time | 4 hour, 8 hour, 20 hour, 24 hour, Day 2, Day 5, Day 8, Day 16 |
| Measure | Description | Time Frame |
|---|---|---|
| FLow cytometry | CD surface subtyping for each sampling | 4 hour, 8 hour, 20 hour, 24 hour, Day 2, Day 5, Day 8, Day 16 |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of GFP expressing neutrophils following ex vivo infection with gfp report viral vector combined with CD surface phenotypes. | 4 hour, 48 hour, Day 8, Day 16 |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pusan National University Medical college | Busan | 50612 | South Korea |
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