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The prevalence of Vitamin D deficiency is significantly higher in adults with overweight/obesity compared to those with normal body mass index (BMI). The "entrapment" of Vitamin D in adipose tissue due to impaired lipolytic stimulation and/or adipose tissue dysfunction has been proposed as the driving mechanism. Exercise training has been proposed as a promising strategy to increase mobilization of Vitamin D from adipose tissue, given its well described role in stimulating lipolysis. Indeed, a recent study revealed that participation in moderate-intensity cardiovascular type exercise over winter can mitigate the decline in 25-hydroxyvitamin D [25(OH)D] in adults with overweight/obesity, independent of weight loss. The aim of this study is to investigate the impact of hybrid-type high-intensity interval training over winter on vitamin D metabolism, in adults with overweight/obesity.
Thirty adults with overweight/obesity (both males and females) who will meet the inclusion criteria will be randomly assigned to either an Exercise group (n=15) or a Control group (n=15). The Exercise group will participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period, while receiving a balanced diet. The Control group will receive a balanced diet but will not participate in exercise training. Both groups will provide a resting blood sample and undergo assessment of their body composition (via bioelectrical impedance analysis), daily dietary intake (via dietary recalls) and physical activity level (via accelerometry) at baseline (prior to intervention), 6 weeks and 12 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise group | Experimental | Exercise group will participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period, while receiving a balanced diet |
|
| Control group | Active Comparator | Control group will receive a balanced diet but will not participate in exercise training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise training | Other | Receive a balanced diet and participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in 25-hydroxyvitamin D concentration | 25-OH-VD will be quantitatively determined in serum | At baseline, 6 weeks and 12 weeks |
| Change in plasma Vitamin D binding protein concentration | Vitamin D binding protein concentration will be determined in plasma | At baseline, 6 weeks and 12 weeks |
| Change in calcium concentration | Calcium concentration will be determined in serum | At baseline, 6 weeks and 12 weeks |
| Change in albumin concentration | Albumin concentration will be determined in serum | At baseline, 6 weeks and 12 weeks |
| Change in aspartate aminotransferase (SGOT) concentration | SGOT concentration will be determined in serum on a Clinical Chemistry analyzer | At baseline, 6 weeks and 12 weeks |
| Change in alanine aminotransferase (SGPT) concentration | SGPT concentration will be determined in serum on a Clinical Chemistry analyzer | At baseline, 6 weeks and 12 weeks |
| Change in gamma-glutamyl transferase (γ-GT) concentration | γ-GT concentration will be determined in serum on a Clinical Chemistry analyzer | At baseline, 6 weeks and 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in reduced glutathione concentration | Reduced glutathione concentration will be determined in blood erythrocytes | At baseline, 6 weeks and 12 weeks |
| Change in oxidized glutathione concentration |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dimitrios Draganidis, PhD | Contact | +302431047078 | ddraganidis@uth.gr | |
| Ioannis G Fatouros, PhD | Contact | 2431047047 | ifatouros@uth.gr |
| Name | Affiliation | Role |
|---|---|---|
| Dimitrios Draganidis, PhD | University of Thessaly | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Physical Education and Sport Science, University of Thessaly | Recruiting | Trikala | Karyes | 42100 | Greece |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Control | Other | Receive a balanced diet but abstain from any type of exercise training |
|
Oxidized glutathione concentration will be determined in blood erythrocytes
| At baseline, 6 weeks and 12 weeks |
| Change in dietary intake | Dietary intake habits will be assessed through dietary recalls | At baseline, 6 weeks and 12 weeks |
| Change in physical activity level | Physical activity will be assessed via accelerometry | At baseline, 6 weeks and 12 weeks |
| Change in body composition | Body composistion will be assessed via bioelectrical impedance analysis (BIA) | At baseline, 6 weeks and 12 weeks |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |