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| ID | Type | Description | Link |
|---|---|---|---|
| CER-BDX 2025-136 | Other Identifier | Comité d'Etique - Centre Ethique et Recherche en Santé de Bordeaux |
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Congenital heart defects affect 1 in 100 births in France, with rising prevalence due to better care. Despite improved survival, 40% of children post-surgery face neurological impairments, and some of them show brain lesions. Causes include heart defects, genetic syndromes, and surgeries. Some heart defects and support systems increase cerebral risks. Monitoring cerebral perfusion is difficult to assess but emerging ultrafast ultrasound offers real-time, non-invasive blood flow insights.
Congenital heart defects affect 1 in 100 live births in France. While incidence remains stable, prevalence is rising due to improved medical care, with cases expected to double by 2050. Despite increased survival, neurological comorbidities remain a major concern, with 40% of patients undergoing childhood cardiac surgery experiencing impairments and 73% presenting MRI-detectable brain lesions postoperatively. These injuries result from congenital heart defects, haemodynamic disturbances, genetic syndromes, and neonatal surgeries with extracorporeal circulation.
Some heart defects, such as systemic-to-pulmonary shunts and cyanotic heart diseases, impair cerebral perfusion, increasing the risk of hypoxia and stroke. Mechanical circulatory support systems (e.g. ECMO, cardiopulmonary bypass) also contribute to cerebral risks due to hypoperfusion and clotting complications.
Cerebral autoregulation helps maintain stable perfusion despite blood pressure variations. However, bedside cerebral perfusion monitoring remains challenging leading to reliance on indirect methods like near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD), both with limitations. Ultrafast ultrasound (UFUS) is an emerging non-invasive technique that enables real-time quantification of cerebral blood flow, offering new insights into neonatal cerebral haemodynamics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient receiving a transcranial Doppler | Every patient receiving a transcranial Doppler in routine care in our CHD unit of intensive care and anaesthesiology for cardiovascular surgery department |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrafast ultrasound (UFUS) | Other | Ultrafast ultrasound imaging(UFUS), ultrasound images at a very high rate, using a Verasonics system (ultrasound open platform). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral blood volume variation | Depending on stage of medico-surgical treatment | at baseline |
| Cerebral blood volume variation | Depending on hemodynamic or ventilatory situation, and exposure to vasoactive or neuroactive drugs. | at baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Evolution of Arterial blood pressure | at baseline | |
| Evolution of central venous blood pressure | at baseline | |
| Evolution of left atrial pressure |
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Inclusion Criteria:
Exclusion Criteria:
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Every patient, under two years old, receiving a transcranial Doppler in routine care in our CHD unit of intensive care and anaesthesiology for cardiovascular surgery department.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Olivier VILLEMAIN, MD,PhD | Contact | +33 5 24 54 94 79 | +33 | olivier.villemain@chu-bordeaux.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Haut Lévêque Cardiology Hospital | Pessac | France | 33604 | France |
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| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D006330 | Heart Defects, Congenital |
| ID | Term |
|---|---|
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
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| at baseline |
| Evolution of SpO2 | at baseline |
| Evolution of SaO2 | at baseline |
| Evolution of SvO2 | at baseline |
| Evolution of PaCO2 | at baseline |
| Evolution of PaO2 | at baseline |
| Evolution of Hemoglobinemia | at baseline |
| Inotropic drugs dosages | at baseline |
| Vasopressive drugs dosages | at baseline |
| Sedation dosages | at baseline |
| Analgesia dosages | at baseline |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |