Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Patients with CTEPH referred for evaluation and conduction of BPA undergo standard of care diagnostic tests and treatment. This includes conventional echocardiographic, RHC and non-invasive (CT/CMR) or invasive (coronary angiography) coronary artery disease work-up. BPA will be conducted in generally 5 to 6 consecutive sessions. CMR will be performed prior to first and following the last intervention. Patient recruitment will be performed within 3 years, that is the last BPA session of the last patient in will have been performed at 3 years time.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CTEPH patient |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Impact of BPA on cardio-pulmonary vascular physiology | 1a) Changes in right cardiac function (RV EF %) | 1 year |
| Impact of BPA on cardio-pulmonary vascular physiology | 1b) Changes in cardiac function (RV GLS%) | 1 year |
| Impact of BPA on cardio-pulmonary vascular physiology | 2a) Changes in pulmonary artery flow (peak flow m/s) | 1 year |
| Impact of BPA on cardio-pulmonary vascular physiology | 2b) Changes in pulmonary artery flow (mean flow m/s) | 1 year |
| Impact of BPA on cardio-pulmonary vascular physiology | 2c) Changes in pulmonary artery flow (pulse wave velocity m/s) | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Impact of BPA on cardio-pulmonary vascular physiology | 1a) Change in LV tissue composition - T1 (ms) | 1 year |
| Impact of BPA on cardio-pulmonary vascular physiology | 1b) Change in LV tissue composition - ECV (%) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
All CTEPH patients to undergo BPA
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sören Jan Backhaus, MD | Contact | 06032-996-2620 | soeren.backhaus@outlook.de | |
| Andreas Rolf, MD | Contact | 06032-996-2620 | a.rolf@kerckhoff-klinik.de |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kerckhoff-Klinik | Recruiting | Bad Nauheim | Hesse | 61231 | Germany |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| 1 year |
| Impact of BPA on cardio-pulmonary vascular physiology | 2) Change in RA phasic function (%). | 1 year |