Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Assessement of retinal microvasculature detected by OCT-angio after peribulbar &retrobulbar anesthesia in cases undergoing cataract surgery .
prospective , interventional,comparative , clinical study utilizing a pre-post, within-subject design ,which will be conducted in the Department of Ophthalmology ,Sohag University Hospital ,Egypt.
Optical coherence tomography angiography (OCTA) will be performed before and after the administration of retrobulbar and peribulbar local anesthesia in the same cohort of patients, in order to evaluate the immediate effects of the anesthetic intervention on retinal microvascular parameters.the study will be conducted on patients aged 40-80 years with elective cataract surgery requiring regional block.the study will be divided into two main groups :
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group A | Active Comparator | peribulbar anesthesia injection of two anesthetic agents ( lidocaine 2 %+ hyaluronidase 150IU\ML ) |
|
| group A1 | Active Comparator | peribulbar anesthesia injection ( mepivacaine 2% + hyaluronidase 150IU\ML ) |
|
| group B | Active Comparator | retrobulbar anesthesia injection ( lidocaine 2 %+ hyaluronidase 150IU\ML ) |
|
| group B1 | Active Comparator | retrobulbar anesthesia injection ( mepivacaine 2% + hyaluronidase 150IU\ML ) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Local Anesthesia (peribular injection of both lidocaine 2 % and hyaluronidase 150IU\ML) | Drug | peribular injection of both lidocaine 2 % and hyaluronidase 150IU\ML |
|
| Measure | Description | Time Frame |
|---|---|---|
| Macular superficial capillary plexus (SCP) and deep capillary plexus (DCP | to detect degree of changes in vessel density at superficial and deep macular plexuses before and after injection of each group of anesthesia | ntervention & data collection :4-6 monthes |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
opacities, etc). 3. Patients with any other retinal vascular diseases (retinal vein occlusion, central serous chorioretinopathy, age-related macular degeneration, etc).
4. Patients who have had previous intravitreal injections or Laser treatment. 5. Patients who underwent previous vitreoretinal surgeries. 6. Patients with uncontrolled glaucoma or ocular inflammations (eg: vitritis). 7.Patients with diabetes mellitus or hypertension.
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Amira aldesoky abdelazeem ahmed, resident | Contact | 01055330581 | amera.desouky@med.sohag.edu.eg | |
| Mohamed Anber Abdellatif, professor | Contact | 01009801966 |
Not provided
Not provided
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32944557 | Result | Ali H, Eissa S, Magdy H, Khashba M. Dexmedetomidine as an Additive to Local Anesthesia for Decreasing Intraocular Pressure in Glaucoma Surgery: A Randomized Trial. Anesth Pain Med. 2020 Jun 27;10(3):e100673. doi: 10.5812/aapm.100673. eCollection 2020 Jun. | |
| 32053551 | Result | Rao HL, Pradhan ZS, Suh MH, Moghimi S, Mansouri K, Weinreb RN. Optical Coherence Tomography Angiography in Glaucoma. J Glaucoma. 2020 Apr;29(4):312-321. doi: 10.1097/IJG.0000000000001463. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Local Anesthesia (peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML) | Drug | peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML |
|
| Local Anesthesia (retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\ML) | Drug | retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\ML |
|
| local Anesthesia (retrobulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML) | Drug | retrobulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML |
|
| 34748794 | Result | Kalra G, Zarranz-Ventura J, Chahal R, Bernal-Morales C, Lupidi M, Chhablani J. Optical coherence tomography (OCT) angiolytics: a review of OCT angiography quantitative biomarkers. Surv Ophthalmol. 2022 Jul-Aug;67(4):1118-1134. doi: 10.1016/j.survophthal.2021.11.002. Epub 2021 Nov 5. |
| ID | Term |
|---|---|
| D000772 | Anesthesia, Local |
| ID | Term |
|---|---|
| D000765 | Anesthesia, Conduction |
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |
Not provided
Not provided