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| ID | Type | Description | Link |
|---|---|---|---|
| INN2024003 | Other Grant/Funding Number | Institut d'Investigació i Innovació Parc Taulí | |
| CIR2023014 | Other Grant/Funding Number | Institut d'Investigació i Innovació Parc Taulí |
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| Name | Class |
|---|---|
| Institut de Ciències Fotòniques (ICFO) | UNKNOWN |
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Proof-of-concept observational study including ICU patients undergoing a PLR maneuver. Local microvasculature will be assessed with the hDOS platform on the brachioradialis muscle, deriving the microvascular blood flow index (BFI) and tissue oxygen saturation (StO2). CO will be assessed via an invasive hemodynamic monitor based on pulse waveform analysis through the patient's arterial line. The correlation over time between CO and microvascular parameters, and the ability of microvascular variables for predicting a positive CO response (increase > 10%) will be assessed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Critical care patient | Critical care patients with their blood pressure invasively monitored through an arterial line |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Passive Leg Raising maneuver | Other | The PLR will be performed using automatic bed adjustment: Starting from a semi-recumbent position, the lower limbs will be elevated to a 45° angle while the trunk will be moved from semi-recumbent to supine. After three minutes, subjects will be returned to the initial semi-recumbent position. |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiac Output Response | The relative increase in % of the Cardiac Output (CO), from baseline during the Passive Leg Raising (PLR) test (at 60-120 seconds within the maneuver), will be calculated. Those subjects with a relative increase equal to or above 10% will be classified as CO-responders to the PLR. On the other hand, if the increase in CO during the PLR is below 10%, subjects will be classified as non-responders. | During procedure |
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Inclusion Criteria:
Exclusion Criteria:
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ICU patients with their blood pressure invasively monitored through an arterial line
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jaume Mesquida Senior Clinical Researcher, MD | Contact | +34 616722287 | jmesquida@tauli.cat |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Parc Taulí Hospital Universitari | Recruiting | Sabadell | Spain/ Barcelona | 08208 | Spain |
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| ID | Term |
|---|---|
| D016638 | Critical Illness |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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