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| Name | Class |
|---|---|
| Kukje Pharma | OTHER |
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This study compares the immediate therapeutic and mucin-secreting effects 30 minutes after instillation of 3% diquafosol and 2% rebamipide in dry eye disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| R) DQS, L) REB | Other | This is a paired-eye design study. Patients were randomly assigned to receive 3% diquafosol in the right eye and 2% rebamipide in the contralateral left eye, with the treatment assignment blinded to the examiner and patients. |
|
| R) REB, L) DQS | Other | This is a paired-eye design study. Patients were randomly assigned to receive 3% diquafosol in the left eye and 2% rebamipide in the contralateral right eye, with the treatment assignment blinded to the examiner and patients. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3% diquafosol (right eye) and 2% rebamipide (left eye) | Drug | 3% diquafosol was instilled in the right eye and 2% rebamipide in the left eye. |
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| Measure | Description | Time Frame |
|---|---|---|
| visual analog scale (VAS) score | Unit: points | Before instillation of eyedrops, and 30 minutes after instillation of eyedrops |
| tear breakup time (TBUT) | Unit: Seconds | Before instillation of eyedrops, and 30 minutes after instillation of eyedrops |
| ocular staining score (OSS) | National Eye Institute Scale, 0-15 | Before instillation of eyedrops, and 30 minutes after instillation of eyedrops |
| tear meniscus height (TMH) | Unit: mm | Before instillation of eyedrops, and 30 minutes after instillation of eyedrops |
| lipid layer thickenss (LLT) | Unit: nm | Before instillation of eyedrops, and 30 minutes after instillation of eyedrops |
| corneal sensitivity (esthesiometer) | Unit: mm | Before instillation of eyedrops, and 30 minutes after instillation of eyedrops |
| Measure | Description | Time Frame |
|---|---|---|
| tear MUC1 concentration | measured using enzyme-linked immunosorbent assay (ELISA) | Before instillation of eyedrops, and 30 minutes after instillation of eyedrops |
| tear MUC5AC concentration | measured using enzyme-linked immunosorbent assay (ELISA) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Korea University Anam Hospital | Seoul | 02841 | South Korea |
The data that support the findings of this study are not openly available due to reasons of sensitivity and may available from the corresponding author upon reasonable request.
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| ID | Term |
|---|---|
| D015352 | Dry Eye Syndromes |
| ID | Term |
|---|---|
| D007766 | Lacrimal Apparatus Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| C403315 | diquafosol |
| C052785 | rebamipide |
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This is a paired-eye design study, where patients received 3% diquafosol in one eye and 2% rebamipide in the contralateral eye.
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| 2% rebamipide (right eye) and 3% diquafosol (left eye) | Drug | 2% rebamipide was instilled in the right eye and 3% diquafosol in the left eye. |
|
| Before instillation of eyedrops, and 30 minutes after instillation of eyedrops |