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This single-center prospective cohort study aims to describe the distribution of umbilical-cord blood vitamin A concentrations in extremely preterm infants (<32 weeks' gestation) and to evaluate whether low cord blood vitamin A is associated with increased risk of neonatal morbidities such as bronchopulmonary dysplasia (BPD), necrotising enterocolitis (NEC), severe intraventricular haemorrhage (IVH), retinopathy of prematurity (ROP), periventricular leukomalacia (PVL), high-grade patent ductus arteriosus (hsPDA), respiratory distress syndrome (RDS), sepsis and death before discharge.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Extremely Preterm Infants |
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| Measure | Description | Time Frame |
|---|---|---|
| Composite adverse neonatal outcome (any of death, moderate-severe BPD, NEC≥stage II, IVH≥grade III, ROP≥stage 3, PVL, hsPDA, culture-proven sepsis) | From birth to 36 weeks' PMA or discharge, up to 3 months chronological age. |
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Inclusion Criteria:
Gestational age <32 weeks Birth at First Hospital of Jilin University Umbilical cord blood sample obtained within 24 h Parental written informed consent
Exclusion Criteria:
Major congenital malformation or chromosomal abnormality Refusal of consent
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Preterm neonates (gestational age <32 weeks)
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hui Wu | Contact | 13134318877 | wuhui@jlu.edu.cn |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30500928 | Result | Allen LH, Miller JW, de Groot L, Rosenberg IH, Smith AD, Refsum H, Raiten DJ. Biomarkers of Nutrition for Development (BOND): Vitamin B-12 Review. J Nutr. 2018 Dec 1;148(suppl_4):1995S-2027S. doi: 10.1093/jn/nxy201. |
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