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This study compares two topical agents for the treatment of fungal infection of the external auditory canal: boric acid and a 10% povidone-iodine solution
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Boric acid group | Active Comparator |
| |
| Povidone iodine group | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Boric acid | Drug | Boric acid is topically applied to the external auditory canal for treatment of otomycosis |
|
| Measure | Description | Time Frame |
|---|---|---|
| objective clinical response | clinical response is assessed by ear examination by presence or absence of fungal hyphae inside the external auditory canal | Days 7, 14, and 28 after treatment |
| Microbiological response | Microbiological response is evaluated by obtaining cultures from the external auditory canal searching for fungal growth | day 28 after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| subjective pain response | pain is evaluated on a visual analogue scale from 0 to 10 | days 7, 14, and 28 after treatment |
| subjective itching response | itching is evaluated on a visual analogue scale from 0 to 10 |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine, Mansoura University | Al Mansurah | Dakahlia Governorate | 35511 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23984100 | Result | Philip A, Thomas R, Job A, Sundaresan VR, Anandan S, Albert RR. Effectiveness of 7.5 percent povidone iodine in comparison to 1 percent clotrimazole with lignocaine in the treatment of otomycosis. ISRN Otolaryngol. 2013 Jul 25;2013:239730. doi: 10.1155/2013/239730. eCollection 2013. | |
| 28549873 | Result | Mofatteh MR, Naseripour Yazdi Z, Yousefi M, Namaei MH. Comparison of the recovery rate of otomycosis using betadine and clotrimazole topical treatment. Braz J Otorhinolaryngol. 2018 Jul-Aug;84(4):404-409. doi: 10.1016/j.bjorl.2017.04.004. Epub 2017 May 6. |
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| ID | Term |
|---|---|
| D059249 | Otomycosis |
| ID | Term |
|---|---|
| D009181 | Mycoses |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D004427 | Ear Diseases |
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| ID | Term |
|---|---|
| C032688 | boric acid |
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| Povidone iodine 10% | Drug | 10% povidone iodine solution is topically applied to the external auditory canal for the treatment of otomycosis |
|
| days 7, 14, and 28 after treatment |
| 12572722 | Result | del Palacio A, Cuetara MS, Lopez-Suso MJ, Amor E, Garau M. Randomized prospective comparative study: short-term treatment with ciclopiroxolamine (cream and solution) versus boric acid in the treatment of otomycosis. Mycoses. 2002 Oct;45(8):317-28. doi: 10.1046/j.1439-0507.2002.00737.x. |
| D010038 |
| Otorhinolaryngologic Diseases |