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Orthokeratology (OK) has been demonstrated to be an effective intervention for slowing axial elongation in children with myopia. The proposed mechanism of action is the induction of peripheral myopic defocus, which reduces relative peripheral hyperopia on the retina.
This study aims to evaluate changes in relative peripheral retinal refraction before and after OK lens wear using wide-field multispectral retinal refractive topography. The study will also investigate the relationship between these retinal refractive changes and the effectiveness of OK in controlling axial elongation.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| orthokeratology | Device | All participants will be fitted with orthokeratology lenses of the same design. The primary objective is to assess changes in relative peripheral retinal refraction before and after lens wear. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in axial length growth(ALG) | Axial length will be measured using an ocular biometer (AL-Scan, NIDEK, Japan). Axial length growth (ALG) will be defined as the difference between the 1-year measurement and baseline. | Change from baseline in axial length at 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Relative Peripheral Retinal Refraction | Retinal refractive power will be measured using multispectral retinal refractive topography. Relative peripheral retinal refraction will be calculated as the difference between peripheral and central retinal refractive power. Changes from pre- to post-orthokeratology lens wear will be evaluated. | Baseline (pre-lens wear), 1 month, 6 months, and 12 months after orthokeratology lens wear. |
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Inclusion Criteria:
Exclusion Criteria:
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Children aged 8 to 15 years with myopia who are eligible for and fitted with orthokeratology lenses. Participants must demonstrate the ability to maintain adequate compliance with lens wear and follow-up requirements.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xiaoyan Yang | Tianjin | Tianjin Municipality | 300020 | China |
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| ID | Term |
|---|---|
| D009216 | Myopia |
| D012030 | Refractive Errors |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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