Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| The First Affiliated Hospital of Henan University of Science and Technology | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
1.Background Handgrip strength , a core indicator of muscle function, has been confirmed to be significantly associated with the clinical prognosis of patients with liver cirrhosis. However, no studies have explored its correlation with portal venous hemodynamics. 2. Objective The purpose of the study is to examine the effects of Handgrip strength on portal vein and left gastric vein pressure, blood flow velocity and direction in patients with liver cirrhosis.
3. Method: observational study. Detection Timing: Doppler ultrasound was employed to determine the portal flow velocity and direction at baseline and during the handgrip strength test in cirrhotic patients with a history of variceal bleeding. Three days later, prior to TIPS placement, the pressures in the portal pressure and gastric vein pressure were measured both before and after handgrip strength. Furthermore, carvedilol and vasoactive drugs were discontinued three days before the study commenced. 4. Elaboration of the Research Hypothesis 4.1. Core Hypothesis The handgrip strength level in patients with liver cirrhosis is correlated with portal venous system hemodynamic indices. Specifically, enhanced handgrip strength may affect portal hypertension and the hemodynamics of varicose veins by improving systemic muscle function or circulatory status. 4.2. Speculation on potential mechanisms Association between muscle function and circulation: As a representative of systemic muscle function, increased handgrip strength may reflect an increase in cardiac output or changes in splanchnic vascular resistance, thereby influencing portal venous hemodynamics.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Portal pressure measurement group |
| ||
| Doppler Ultrasound Measurement Group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Handgrip strength | Device | Jamar Hand Dynamometer, from Illinois, USA. Maximum handgrip strength was measured three times, with each measurement lasting 3 seconds and a 1-minute interval between tests |
| Measure | Description | Time Frame |
|---|---|---|
| portal pressure | Prior to TIPS, the pressure monitoring catheter was connected to the pressure-measuring device. Subsequently, the pressures in both the portal vein and left gastric vein were measured simultaneously at baseline and during the handgrip strength test. | through study completion, an average of 5 minutes |
| left gastric vein pressure | Prior to TIPS, the pressure monitoring catheter was connected to the pressure-measuring device. Subsequently, the pressures in both the portal vein and left gastric vein were measured simultaneously at baseline and during the handgrip strength test. | through study completion, an average of 5 minutes |
| portal flow velocity | At least 72 hours after the baseline handgrip strength and during the handgrip strength phase, measurements were conducted at intervals of 15 seconds, 30 seconds, 45 seconds, and 60 seconds after the release of strength related to the handgrip Strength | |
| Portal vein blood flow direction | At least 72 hours after the baseline handgrip strength and during the handgrip strength phase, measurements were conducted at intervals of 15 seconds, 30 seconds, 45 seconds, and 60 seconds after the release of strength related to the handgrip Strength |
| Measure | Description | Time Frame |
|---|---|---|
| Serum albumin (g / l) | Pre-TIPS baseline characteristics ,date (n=32) | Baseline |
| alanine aminotransferase(IU / L) | Pre-TIPS baseline characteristics, date (n=32) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
This observational study was performed in two centers in China (The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology [Luoyang], and Shanxi Provincial People's Hospital [Taiyuan]) . They serve as the major tertiary referral center for the management of liver cirrhosis and its complications in our country.
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Henan University of Science and Technology | Luoyang | Henan | 471003 | China | ||
The way of sharing IPD: Sharing and email consultation will begin after December 31, 2027.
Data collection and Management: Case record forms and electronic data captures.
Sharing and email consultation will begin after December 31, 2027
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Baseline |
| aspartate aminotransferase (IU / L) | Pre-TIPS baseline characteristics ,date (n=32) | Baseline |
| Total bilirubin (µmol / l) | Pre-TIPS baseline characteristics ,date (n=32) | Baseline |
| Prothrombin time (second) | Pre-TIPS baseline characteristics ,date (n=32) | Baseline |
| Fasting blood glucose (mmol / l) | Pre-TIPS baseline characteristics ,date (n=32) | Baseline |
| triglyceride (mmol / l) | Pre-TIPS baseline characteristics ,date (n=32) | Baseline |
| Total cholesterol (mmol / l) | Pre-TIPS baseline characteristics ,date (n=32) | Baseline |
| Serum creatinine (µmol / l) | Pre-TIPS baseline characteristics ,date (n=32) | Baseline |
| Serum potassium (mmol / l) | Pre-TIPS baseline characteristics ,date (n=32) | Baseline |
| Serum sodium (mmol / l) | Pre-TIPS baseline characteristics ,date (n=32) | Baseline |
| Serum chloride (mmol / l) | Pre-TIPS baseline characteristics ,date (n=32) | Baseline |
| Platelet count (× 109 / mm3) | Pre-TIPS baseline characteristics ,date (n=32) | Baseline |
| height | Baseline |
| weight | Baseline |
| Model for end-stage liver disease score | Model for end-stage liver disease score: 6-40, the higher scores mean a worse outcome. | Baseline |
| Child-Pugh score | Child-Pugh score: 5-15, the higher scores mean a worse outcome | Baseline |
| Esophageal varices before endoscopic treatment | The diagnosis of esophageal varices and variceal bleeding in patients is confirmed by upper gastrointestinal endoscopy. | Baseline |
| Collateral vessels before TIPS placement | Vascular angiography was performed prior to TIPS placement to diagnose collateral circulation. date (n=32) | Baseline |
| Ascites | Prior to TIPS, ascites was evaluated by ultrasound in 32 patients with liver cirrhosis. | Baseline |
| Prior overt hepatic encephalopathy | Baseline |
| Etiology of cirrhosis | Baseline |
| Age | Baseline |
| Sex | Baseline |
| Handgrip Strength | Baseline |
| Shanxi Provincial People's Hospital |
| Taiyuan |
| Shanxi |
| 030012 |
| China |