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| ID | Type | Description | Link |
|---|---|---|---|
| K23HL178394 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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Menopause is associated with the acceleration of many comorbidities, including cardiovascular disease. Whether HIV and menopause together increase cardiovascular disease risk is a key knowledge gap. The goal of this observational study is to address this knowledge gap by looking at the role of menopause on cardiovascular disease risk factors such as insulin resistance, hypertension, hyperlipidemia, and carotid atherosclerosis using previously collected data. The investigators will look at underlying causes for cardiovascular diseases worsening in menopausal women with HIV by looking at the role of increased inflammation in the body and whether this is altered by weight. The investigators achieve this by enrolling participants who are willing to undergo a whole body MRI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MACS-WIHS Combined Cohort Study |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whole body MRI | Diagnostic Test | Whole body MRI will be performed as part of a study protocol |
|
| Measure | Description | Time Frame |
|---|---|---|
| Markers of immune activation and inflammation | sCD14 (monocyte activation), sCD163 (M2 macrophage activation), CRP (inflammation), IL-6 (inflammation), IP-10 (interferon-inducible protein), TNFα (inflammation), MCP-1 (inflammation), sTNFRI & RII (inflammation). There are no units as they will be normalized based upon their interquartile range. | These markers will be measured from blood work collected at the scheduled study visit [Day 1] close to the time of MRI and thus will be collected at only one time point. |
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Inclusion Criteria:
Exclusion Criteria:
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Women with HIV who are enrolled in the MWCCS.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rebecca A Abelman, MD | Contact | 415-221-4810 | 23613 | rebecca.abelman@ucsf.edu |
| Stacy Polos | Contact | 415-689-0915 | stacy.polos@ucsf.edu |
| Name | Affiliation | Role |
|---|---|---|
| Rebecca Abelman, MD | University of California, San Francisco | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, San Francisco | Recruiting | San Francisco | California | 94110 | United States |
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| ID | Term |
|---|---|
| D002340 | Carotid Artery Diseases |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |