Comparing Microneedling and Injectable Platelet Rich Fibrin to Hyaluronic Acid In Papilla Reconstruction

Comparative Evaluation of Microneedling With Injectable PRF and Hyaluronic Acid for Papilla Reconstruction: A Randomized Clinical Trial

This randomized split-mouth clinical trial aims to compare the clinical effectiveness of microneedling combined with injectable platelet-rich fibrin (i-PRF) versus hyaluronic acid (HA) gel injection in the reconstruction of Class I interdental papilla loss. The study hypothesizes that MN + i-PRF will yield greater papillary regeneration, offering a minimally invasive, biologically active alternative to traditional surgical approaches for soft-tissue esthetic rehabilitation.

Inclusion Criteria:

• Plaque index <1
• Gingival index <1
• Class I papillary loss (Nordland and Tarnow classification)
• Probing depth ≤4 mm at the test site
• Inter-proximal bone crest distance ≤7 mm from the contact point.

Exclusion Criteria:

• Pregnancy
• Lactation
• Uncontrolled systemic diseases (e.g., diabetes)
• Anticoagulant therapy
• Recent radiotherapy
• Orthodontic treatment
• Midline diastema
• High frenum attachment
• Class II/III papillary loss.