Cannabidiol and Alcohol Use Disorder Phenotypes

Effects of Full-spectrum Cannabidiol on Alcohol Consumption and Alcohol Use Disorder Phenotypes: Implications for Precision Medicine

The goal of this study is to learn how CBD affects drinking in people who drink alcohol regularly. Researchers want to see if CBD can help people drink less and reduce problems related to alcohol use.

Your participation will include up to five in-person visits over about 13 weeks, including a screening visit, a visit to get your medication, a midpoint visit, an experimental lab session, and a final follow-up visit. You will be assigned to a study medication which you will take daily for 8 weeks while completing daily surveys and weekly virtual check-ins with the research team. During the experimental lab session visit, you will be offered alcohol to drink at the bar lab.

Inclusion Criteria:

1. Age 21-65
2. Have used CBD and cannabis at least once in the last year
3. Regularly drink alcohol
4. Able to provide informed consent and attend in-person study visits

Exclusion Criteria:

1. Current use of medications known to have major interaction with Epidiolex, Marinol, or alcohol
2. Current use of antiepileptic medication or any psychotropic medication besides antidepressants
3. Pregnant, nursing, or planning a pregnancy
4. Medical conditions that contraindicates the use of CBD or alcohol
5. Current medical conditions that may require intensive care during the study period

Not everyone will qualify to be in the study. Other inclusion and exclusion criteria will be evaluated by the study team.