Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| R01NS140610 | U.S. NIH Grant/Contract | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| National Institute of Neurological Disorders and Stroke (NINDS) | NIH |
Not provided
Not provided
Not provided
Not provided
This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventually provide candidate mechanisms to target with pharmacological intervention and inform rehabilitative care for those individuals suffering from symptoms of fatigue in PASC.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PASC Participants - Physical Fatigue Task | Experimental | Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue. |
|
| Control Participants - Physical Fatigue Task | Experimental | Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Physical Fatigue | Behavioral | Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison between PASC and HC - difference in mean Assessment Error | The difference between the level of effort rated by participants, and their average grip force exerted on a grip force dynamometer. Compared between PASC and HC. | Baseline, during experimental protocol. |
| Comparing between PASC and HC - difference in BBB permeability | Collected from and MRI sequence designed to measure BBB permeability. | Baseline, during MRI acquisition. |
| Comparing between PASC and HC - Regions of the brain that are sensitive to Assessment error as a function of disease state | We will examine an fMRI contrast, at the time of effort assessment, between HC and PASC groups. This contrast will examine percent signal change in brain activity. | Baseline, during experimental protocol. |
| The modulatory effect of BBB permeability on the relationship between Neural Activity and Effort Assessment | We will create a structural equation model that includes BBB permeability, fMRI activity, effort assessment behavior, and disease state (PASC/HC). | Baseline, during experimental protocol and MRI aquisition. |
| Comparing between PASC and HC - Difference in momentary subjective fatigue ratings | Measures of subjective fatigue will be collected on self report scale that ranges from 'not fatigued at all' to 'very fatigued'. | Baseline and during fatiguing exertions in the experimental protocol. |
| Comparing between PASC and HC - Difference in Mean Acceptance Rate of Risky Effort Options between rested/baseline and fatigue choices |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Healthy age- and sex-matched controls for PASC - Exclusion criteria: Participants with a history of any of the following will be excluded from the study:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anthony Gonzalez | Contact | 443-923-2716 | gonzalezan@kennedykrieger.org | |
| Vikram Chib, PhD | Contact |
| Name | Affiliation | Role |
|---|---|---|
| Vikram Chib, PhD | Johns Hopkins University; Kennedy Krieger Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kennedy Krieger Institute | Recruiting | Baltimore | Maryland | 21201 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000094024 | Post-Acute COVID-19 Syndrome |
| D005221 | Fatigue |
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Proportion of decisions in which inviduals choice to accept a risky effort opitions over a sure effort option.
| Baseline and during fatiguing exertions in the experimental protocol. |
| Comparing between PASC and HC - Regions of the brain encoding a difference in effort cost between rested/baseline and fatigue choices | We will examine a contrast between chosen effort value pre versus post fatigue, between the HC and PASC groups. This contrast will examine percent signal change in brain activity. | Baseline and during fatiguing exertions in the experimental protocol. |
| The modulatory effect of BBB permeability on the relationship between Neural Activity and change effort-based decision-making | We will create a structural equation model that includes BBB permeability, fMRI activity, change in effort-based decision-making, and disease state (PASC/HC). | Baseline, fatigueing exertion, and during experimental protocol and MRI aquisition |
| Comparing between PASC and HC - Difference in mean assessment error as a function of time | The difference between the level of effort rated by participants, and their average grip force exerted on a grip force dynamometer. Compared between PASC and HC. | Data collections at months 0, 3, 6, 12 |
| Comparing between PASC and HC - Difference in momentary subjective fatigue ratings as a function of time | Measures of subjective fatigue will be collected on self report scale that ranges from 'not fatigued at all' to 'very fatigued'. | Data collections at months 0, 3, 6, 12 |
| Comparing between PASC and HC - difference in BBB permeability as a function of time | Collected from and MRI sequence designed to measure BBB permeability. | Data collections at months 0, 3, 6, 12 |
| Comparing between PASC and HC - Regions of the brain that are sensitive to Assessment error as a function of disease state and time | We will examine a contrast, at the time of effort assessment, between HC and PASC groups, and use time as a covariate. This contrast will examine percent signal change in brain activity. | Data collections at months 0, 3, 6, 12 |
| D007239 |
| Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D000094025 | Post-Infectious Disorders |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |