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| Name | Class |
|---|---|
| North Estonia Medical Centre | OTHER |
| Tartu University Hospital | OTHER |
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A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Right ventricular pacing | Active Comparator |
| |
| Conduction system pacing | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Right ventricular pacing | Device | Pacemaker implantation with RV lead placement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Central systolic blood pressure | One year post implantation of pacemaker |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Silver Heinsar, MD, PhD | Contact | +372 5333 1997 | silver.heinsar@ut.ee |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| North Estonia Medical Centre | Recruiting | Tallinn | Harju | 13419 | Estonia |
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| ID | Term |
|---|---|
| D054537 | Atrioventricular Block |
| ID | Term |
|---|---|
| D006327 | Heart Block |
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| Conduction system pacing | Device | Pacemaker implantation with conduction system (LBBAP) lead placement |
|
| Tartu University Hospital | Recruiting | Tartu | Tartu | 50406 | Estonia |
|
| D000075224 |
| Cardiac Conduction System Disease |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |