Adjuvant Ultra-Hypofractionated vs Hypofractionated Radiotherapy for Early Breast Cancer

Adjuvant Ultra Hypofractionation Radiotherapy Versus Hypofractionation Radiotherapy in Treatment of Early Invasive Breast Cancer

breast-conserving surgery. One group receives ultra-hypofractionated radiotherapy (26 Gy in 5 sessions over 1 week), while the other group receives hypofractionated radiotherapy (40 Gy in 15 sessions over 3 weeks). The study aims to compare skin toxicity, cosmetic outcomes, and local cancer control between thetwo schedules . Participants are followed during and after radiotherapy for up to 24 months.

Inclusion Criteria:• Histological diagnosis of breast adenocarcinoma

• Prior breast conservative surgery negative resection margins (3 mm)
• Pathological stage pT1-pT2, N0-1, pT3-N0, M0
• No macroscopic evidence of distant metastases at diagnosis
• Age 18-80 years
• Female patients
• Normal hematological and biochemical laboratory tests
• Written informed consent was obtained from all patients

Exclusion Criteria: • Patients underwent mastectomy.

• Locally advanced disease pT4, N2,3.
• Positive surgical margins
• Prior thoracic radiation
• Synchronous second primary tumor
• Distant metastases
• Pregnancy
• Presence of a concomitant psychiatric disorder precluding an aware informed consent.
• Age >80 years
• Low risk patient meeting all the following criteria (more than or equal 65 years, PT1, grade 1 or 2, +ER, -Her2nu, N0, M0).