Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration

Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration (SERENE)

This study is a pragmatic, randomized controlled pilot trial comparing remimazolam with propofol for endoscopic procedures, designed to assess the feasibility and clinical outcomes associated with implementing a pragmatic randomized trial of sedation practices in the endoscopy setting.

Inclusion Criteria:

• Aged 18 years of age or older
• Planned endoscopic procedure
• American Society of Anesthesiologists (ASA) Physical Status I to III

Exclusion Criteria:

• Planned tracheal intubation
• Procedure length anticipated to exceed 45 minutes
• Previously participated in the trial
• Pregnant (defined as a positive test using pre-procedural clinical testing performed as part of their routine care) or breastfeeding
• Allergy or hypersensitivity to one of the study medications
• Blind, deaf, or unable to communicate in English
• Co-enrollment in other interventional studies that, in the opinion of the site investigator and/or their delegate, might interfere with study participation, collection, or interpretation of the study data