Effect of Nutritional Supplement Alpha-ketoglutarate for Age-related Ocular Disease

Effect of Nutritional Supplement Alpha-ketoglutarate for Age-related Ocular Disease: An Open Label, Single Arm Study to Evaluate the Effect of Alpha-ketoglutarate Administered Orally in Patients With Age-related Ocular Diseases (Metabolic Eye Therapy)

The aims of the study are as follows:

1. Determine how the eye absorbs supplements taken orally.
2. Look for specific signs in the proteins and substances in the eyes of people with eye diseases who are also taking nutritional supplements.

Inclusion Criteria:

1. Able and willing to give written informed consent
2. Able to attend all study visits and complete the study procedures
3. Women of child-bearing potential must have a negative pregnancy test within 2 weeks before cataract surgery. A pregnancy test is not required for postmenopausal women (defined as being at least 12 consecutive months without menses) or those surgically sterilized (those having a bilateral tubal ligation/bilateral salpingectomy, bilateral tubal occlusive procedure, hysterectomy, or bilateral oophorectomy).

Exclusion Criteria:

1. Diabetes and/or thyroid, liver, kidney, bowel, and metabolic diseases or disorders
2. History of supplement allergy or planned major surgery
3. Received any other clinical trial drug within 4 months
4. Calculated creatinine clearance of less than 30 ml/min