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The study's primary goal is to compare the base excess (BE) values-an indicator of metabolic changes-in two groups of patients at Santo Tomás Hospital: those with severe preeclampsia and healthy, pregnant individuals. Researchers will measure these values using an arterial blood gas test before delivery or surgery.
This is a prospective cohort study. The researchers will analyze various blood gas parameters, including pH, lactate, and BE, and then correlate the BE values with clinical variables and negative maternal outcomes.
The expected outcome is that a abnormal BE values will be linked to a greater severity of preeclampsia. If this association is confirmed, BE could serve as an additional marker for predicting the severity of the condition and may lay the groundwork for future research on diagnostic and therapeutic standards based on blood gas analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Severe preeclampsia | Experimental | Pregnant subjects with severe preeclampsia |
|
| Normotensive | Experimental | Pregnant subjects with normal blood pressure |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Arterial Blood gases | Diagnostic Test | Determination of Excess Base in arterial blood gases before delivery / termination of pregnancy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Value of excess base | Total measure of excess base measured by gasometry in an arterial blood sample | Immediately before delivery |
| Hypertensive crisis | Elevation of the blood pressure above 160 (systolic) and 110 (diastolic). | From admission to day three (3) after delivery |
| Measure | Description | Time Frame |
|---|---|---|
| Lactate | Concentration of lactate measured by gasometry in a sample of arterial blood. | Immediately before delivery |
| Bicarbonate | Concentration of bicarbonate measured by gasometry in arterial blood gases |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Francisco Jordan, MD | Contact | +507 6983-0029 | fcojordan19@gmail.com | |
| Adriana Martinz, MD | Contact | amartinzmd@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Osvaldo Reyes, MD | Saint Thomas Hospital, Panama | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Saint Thomas Hospital | Recruiting | Panama City | Provincia de Panamá | Panama |
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| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D001784 | Blood Gas Analysis |
| ID | Term |
|---|---|
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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Both groups will have a blood sample taken for arterial blood gases. This test is not always indicated in severe preeclampsia and very rarely in normal patients. This is he reason we consider the study interventional.
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| Immediately before delivery |
| D003933 | Diagnosis |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D008919 | Investigative Techniques |