Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition

Effect of Physiologic Insulin Intervention on Insulin Sensitivity and Cognition

The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease. It will also provide information about the safety and feasibility of this intervention.

The main questions it aims to answer are:

Does the intervention improve insulin sensitivity (how the body uses glucose)?

Does the intervention improve cognition, measured by the Montreal Cognitive Assessment (MoCA) and the Revised Memory and Behavior Problems Checklist (RMBPC)?

What changes occur in brain glucose uptake (FDG-PET)?

Participants will:

Receive the intervention once a week for 6 months, with each session lasting up to 2 hours

Complete cognitive assessments. Adverse events will be assessed throughout the study.

Inclusion Criteria:

• Mini Mental State Examination (MMSE) score < 25

Exclusion Criteria:

• On daily medication for the specific treatment of anxiety including benzodiazepines.
• An infant, child, or teenager
• A pregnant woman
• A prisoner
• Having any condition that impedes testing of the study hypothesis or are otherwise deemed to be unsuitable (determined by the investigative team).