Role of Omega-6 Fatty Acids in Hepatocellular Carcinoma Development.

Study of Omega-6 Fatty Acids in Patients With Hepatocellular Carcinoma

This observational study investigates the association between serum Omega-6 fatty acids and hepatocellular carcinoma development. Adult HCC patients and age - and gender matched healthy controls will be included. Serum Omega-6 levels will be compared between groups to explore potential correlations with disease presence and severity .

Hepatocellular carcinoma is a leading cause of cancer related deaths worldwide . Omega-6 fatty acids have been suggested to influence liver cancer development .This observational study aims to assess the association between serum Omega-6 fatty acid levels and HCC development .

Adult patients diagnosed with HCC will be recruited from Sohag University Hospital, along with age and gender matched healthy controls . Blood samples will be collected to measure serum Omega-6 levels using standardized bio-chemical assays . clinical and laboratory data , including liver function tests and tumor stage , will also be recorded.

The study will compare Omega-6 levels between HCC patients and controls , and analyze potential correlation with disease severity .Findings may provide insights into the role of Omega-6 fatty acids in HCC pathogenesis and help identify biomarkers for early detection and risk assessment .

Inclusion Criteria:

• 1. Adults aged 18 years and above. 2. Patients with hepatocellular carcinoma (confirmed clinically, laboratory, radiologically, or histopathologically).

  3. Ability and willingness to provide informed written consent. 4. For healthy controls: individuals without liver disease or history of malignancy, matched by age and gender.

  5. For cirrhotic controls: patients with liver cirrhosis without evidence of any malignancy, matched by age and gender.

Exclusion Criteria:

1. History of chronic inflammatory (except for liver cirrhosis or HCC) or autoimmune diseases.

2. Current use of omega-6 or omega-3 fatty acid supplements.

3. Presence of other types of cancer.

4. Pregnant or lactating women.

5. presence of severe comorbid condition.

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