Creation of a Biological Collection for Medical Research Purposes for Patients at the Reference Center for Rare Diseases of the Blood Vessels of the Brain and Eye at Lariboisière Hospital

Constitution d'Une Collection Biologique à Des Fins de Recherche médicale Pour Les Patients du Centre de référence Des Maladies Rares Des Vaisseaux du Cerveau et de l'Oeil à l'hôpital Lariboisière

The aim of establishing a biological collection associated with the existing rare cerebral vascular disease cohort is to identify new prognostic or disease progression biomarkers that could improve patient care or identify new therapeutic targets.

Inclusion Criteria:

• Confirmed diagnosis of a rare cerebral vascular disease of the brain, including:

Familial intracranial aneurysms, cerebral amyloid angiopathy, CADASIL, familial cerebral cavernoma, familial cervical or intracranial artery dissection, vascular leukoencephalopathy (hereditary), familial hemiplegic migraine, cerebral arteriovenous malformation, moya-moya, cerebral venous thrombosis, hereditary retinal tortuosity, cerebro-retinal vasculopathies, other known rare diseases, or other rare diseases that are undetermined or not yet described.

• Participation in the MVCR cohort
• Adults >18 years old
• Affiliation with French social security or beneficiary - Signature of informed consent

Exclusion Criteria:

• Incompatibility with long-term follow-up at CERVCO
• Patient under guardianship/conservatorship
• Pregnant or breastfeeding women
• Patient under AME