The aim of establishing a biological collection associated with the existing rare cerebral vascular disease cohort is to identify new prognostic or disease progression biomarkers that could improve patient care or identify new therapeutic targets.

Inclusion Criteria:

• Confirmed diagnosis of a rare cerebral vascular disease of the brain, including:

Familial intracranial aneurysms, cerebral amyloid angiopathy, CADASIL, familial cerebral cavernoma, familial cervical or intracranial artery dissection, vascular leukoencephalopathy (hereditary), familial hemiplegic migraine, cerebral arteriovenous malformation, moya-moya, cerebral venous thrombosis, hereditary retinal tortuosity, cerebro-retinal vasculopathies, other known rare diseases, or other rare diseases that are undetermined or not yet described.

• Participation in the MVCR cohort
• Adults >18 years old
• Affiliation with French social security or beneficiary - Signature of informed consent

Exclusion Criteria:

• Incompatibility with long-term follow-up at CERVCO
• Patient under guardianship/conservatorship
• Pregnant or breastfeeding women
• Patient under AME

Patients with rare cerebrovascular diseases